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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095290410> ?p ?o ?g. }

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• W2095290410 abstract "A series of new epoxysuccinyl peptides were designed and synthesized to develop a specific inhibitor of cathepsin B. Of these compounds, N-(L-3-trans-ethoxycarbonyloxirane-2-carbonyl)-L-isoleucyl-L-proli ne (compound CA-030) and N-(L-3-trans-propylcarbamoyloxirane-2-carbonyl)-L-isoleucyl-L-prol ine (compound CA-074) were the most potent and specific inhibitors of cathepsin B in vitro. The carboxyl group of proline and the ethyl ester group or the n-propylamide group in the oxirane ring were necessary, the ethyl ester group or the n-propylamide group being particularly effective for distinguishing cathepsin B from other cysteine proteinases such as cathepsins L and H, and calpains." @default.
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• W2095290410 date "1991-03-25" @default.
• W2095290410 modified "2023-10-14" @default.
• W2095290410 title "Novel epoxysuccinyl peptides Selective inhibitors of cathepsin B, in vitro" @default.
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• W2095290410 doi "https://doi.org/10.1016/0014-5793(91)80318-w" @default.
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