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• W2095291788 abstract "L02 and HepG2 cells were exposed to mono-(2-ethylhexyl) phthalate (MEHP) at concentrations of 6.25–100 μM. After 48 h treatment, MEHP decreased HepG2 cell viability in a concentration-dependent manner and L02 cell viability in the 50 and 100 μM groups (p < 0.01). Furthermore, at 24 and 48 h after treatment, MEHP decreased the glutathione levels of HepG2 cells in all treatment groups and in the ΔΨm in L02 and HepG2 cells with MEHP ≥ 25 μM (p < 0.05 or p < 0.01). At 24 h after treatment, MEHP induced activation of caspase3 in all treated HepG2 and L02 cells (p < 0.05 or p < 0.01) except the 100 μM MEHP treatment group. The increase in the Bax to Bcl-2 ratio suggests that Bcl-2 family involved in the control of MEHP-induced apoptosis in these two cell types. The data suggest that MEHP could induce apoptosis of HepG2 cells through mitochondria- and caspase3-dependent pathways." @default.
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• W2095291788 date "2012-05-01" @default.
• W2095291788 modified "2023-10-18" @default.
• W2095291788 title "Mono-2-ethylhexyl phthalate induced loss of mitochondrial membrane potential and activation of Caspase3 in HepG2 cells" @default.
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• W2095291788 doi "https://doi.org/10.1016/j.etap.2012.02.001" @default.
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