FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095292761> ?p ?o ?g. }

• W2095292761 endingPage "295" @default.
• W2095292761 startingPage "290" @default.
• W2095292761 abstract "64Cu-DOTA-AE105 is a novel positron emission tomography (PET) tracer specific to the human urokinase-type plasminogen activator receptor (uPAR). In preparation of using this tracer in humans, as a new promising method to distinguish between indolent and aggressive cancers, we have performed PET studies in mice to evaluate the in vivo biodistribution and estimate human dosimetry of 64Cu-DOTA-AE105. Five mice received iv tail injection of 64Cu-DOTA-AE105 and were PET/CT scanned 1, 4.5 and 22 h post injection. Volume-of-interest (VOI) were manually drawn on the following organs: heart, lung, liver, kidney, spleen, intestine, muscle, bone and bladder. The activity concentrations in the mentioned organs [%ID/g] were used for the dosimetry calculation. The %ID/g of each organ at 1, 4.5 and 22 h was scaled to human value based on a difference between organ and body weights. The scaled values were then exported to OLINDA software for computation of the human absorbed doses. The residence times as well as effective dose equivalent for male and female could be obtained for each organ. To validate this approach, of human projection using mouse data, five mice received iv tail injection of another 64Cu-DOTA peptide-based tracer, 64Cu-DOTA-TATE, and underwent same procedure as just described. The human dosimetry estimates were then compared with observed human dosimetry estimate recently found in a first-in-man study using 64Cu-DOTA-TATE. Human estimates of 64Cu-DOTA-AE105 revealed the heart wall to receive the highest dose (0.0918 mSv/MBq) followed by the liver (0.0815 mSv/MBq), All other organs/tissue were estimated to receive doses in the range of 0.02–0.04 mSv/MBq. The mean effective whole-body dose of 64Cu-DOTA-AE105 was estimated to be 0.0317 mSv/MBq. Relatively good correlation between human predicted and observed dosimetry estimates for 64Cu-DOTA-TATE was found. Importantly, the effective whole body dose was predicted with very high precision (predicted value: 0.0252 mSv/Mbq, Observed value: 0.0315 mSv/MBq) thus validating our approach for human dosimetry estimation. Favorable dosimetry estimates together with previously reported uPAR PET data fully support human testing of 64Cu-DOTA-AE105." @default.
• W2095292761 created "2016-06-24" @default.
• W2095292761 creator A5036678173 @default.
• W2095292761 creator A5042185726 @default.
• W2095292761 creator A5042958651 @default.
• W2095292761 creator A5056398237 @default.
• W2095292761 creator A5071426519 @default.
• W2095292761 creator A5082125631 @default.
• W2095292761 creator A5089128595 @default.
• W2095292761 date "2014-03-01" @default.
• W2095292761 modified "2023-10-18" @default.
• W2095292761 title "Dosimetry of 64Cu-DOTA-AE105, a PET tracer for uPAR imaging" @default.
• W2095292761 cites W101610969 @default.
• W2095292761 cites W1952825395 @default.
• W2095292761 cites W1973717257 @default.
• W2095292761 cites W1987262526 @default.
• W2095292761 cites W1997945349 @default.
• W2095292761 cites W2035434808 @default.
• W2095292761 cites W2047520474 @default.
• W2095292761 cites W2048902262 @default.
• W2095292761 cites W2057382473 @default.
• W2095292761 cites W2064911312 @default.
• W2095292761 cites W2065791048 @default.
• W2095292761 cites W2071694033 @default.
• W2095292761 cites W2074647699 @default.
• W2095292761 cites W2083603357 @default.
• W2095292761 cites W2083707515 @default.
• W2095292761 cites W2092111196 @default.
• W2095292761 cites W2103356717 @default.
• W2095292761 cites W2104845164 @default.
• W2095292761 cites W2105230577 @default.
• W2095292761 cites W2108780137 @default.
• W2095292761 cites W2109699675 @default.
• W2095292761 cites W2117793166 @default.
• W2095292761 cites W2129452239 @default.
• W2095292761 cites W2131321670 @default.
• W2095292761 cites W2132764202 @default.
• W2095292761 cites W2143686200 @default.
• W2095292761 cites W2145704311 @default.
• W2095292761 cites W2154506800 @default.
• W2095292761 cites W2167077736 @default.
• W2095292761 cites W2181503800 @default.
• W2095292761 cites W2460478368 @default.
• W2095292761 doi "https://doi.org/10.1016/j.nucmedbio.2013.12.007" @default.
• W2095292761 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24533988" @default.
• W2095292761 hasPublicationYear "2014" @default.
• W2095292761 type Work @default.
• W2095292761 sameAs 2095292761 @default.
• W2095292761 citedByCount "22" @default.
• W2095292761 countsByYear W20952927612015 @default.
• W2095292761 countsByYear W20952927612016 @default.
• W2095292761 countsByYear W20952927612017 @default.
• W2095292761 countsByYear W20952927612018 @default.
• W2095292761 countsByYear W20952927612019 @default.
• W2095292761 countsByYear W20952927612020 @default.
• W2095292761 countsByYear W20952927612021 @default.
• W2095292761 countsByYear W20952927612022 @default.
• W2095292761 countsByYear W20952927612023 @default.
• W2095292761 crossrefType "journal-article" @default.
• W2095292761 hasAuthorship W2095292761A5036678173 @default.
• W2095292761 hasAuthorship W2095292761A5042185726 @default.
• W2095292761 hasAuthorship W2095292761A5042958651 @default.
• W2095292761 hasAuthorship W2095292761A5056398237 @default.
• W2095292761 hasAuthorship W2095292761A5071426519 @default.
• W2095292761 hasAuthorship W2095292761A5082125631 @default.
• W2095292761 hasAuthorship W2095292761A5089128595 @default.
• W2095292761 hasBestOaLocation W20952927611 @default.
• W2095292761 hasConcept C126322002 @default.
• W2095292761 hasConcept C150903083 @default.
• W2095292761 hasConcept C207001950 @default.
• W2095292761 hasConcept C2775842073 @default.
• W2095292761 hasConcept C2777807558 @default.
• W2095292761 hasConcept C2779931791 @default.
• W2095292761 hasConcept C2780091579 @default.
• W2095292761 hasConcept C2780931953 @default.
• W2095292761 hasConcept C2989005 @default.
• W2095292761 hasConcept C71924100 @default.
• W2095292761 hasConcept C75088862 @default.
• W2095292761 hasConcept C86803240 @default.
• W2095292761 hasConceptScore W2095292761C126322002 @default.
• W2095292761 hasConceptScore W2095292761C150903083 @default.
• W2095292761 hasConceptScore W2095292761C207001950 @default.
• W2095292761 hasConceptScore W2095292761C2775842073 @default.
• W2095292761 hasConceptScore W2095292761C2777807558 @default.
• W2095292761 hasConceptScore W2095292761C2779931791 @default.
• W2095292761 hasConceptScore W2095292761C2780091579 @default.
• W2095292761 hasConceptScore W2095292761C2780931953 @default.
• W2095292761 hasConceptScore W2095292761C2989005 @default.
• W2095292761 hasConceptScore W2095292761C71924100 @default.
• W2095292761 hasConceptScore W2095292761C75088862 @default.
• W2095292761 hasConceptScore W2095292761C86803240 @default.
• W2095292761 hasIssue "3" @default.
• W2095292761 hasLocation W20952927611 @default.
• W2095292761 hasLocation W20952927612 @default.
• W2095292761 hasLocation W20952927613 @default.
• W2095292761 hasLocation W20952927614 @default.
• W2095292761 hasOpenAccess W2095292761 @default.
• W2095292761 hasPrimaryLocation W20952927611 @default.

• next