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• W2095296989 abstract "La leptine, une hormone synthétisée par les cellules du tissu adipeux, agit au niveau de l’hypothalamus pour diminuer l’appétit. Cette action s’exerce par une inhibition de la synthèse de molécules qui stimulent la prise alimentaire (hypocrétines par exemple) et une augmentation de la production de molécules anorexigènes. De fait, des anomalies du système leptinergique sont associées à des pathologies telles que l’obésité. Par ailleurs, la prise alimentaire et l’état métabolique d’un organisme sont connus pour influencer le sommeil. La satiété favorise la survenue du sommeil, tandis qu’à l’opposé, la faim inhibe leur apparition. La leptine diminue les quantités de sommeil paradoxal, et les relations entre leptine et sommeil seraient fondées sur le modèle d’interaction réciproque de régulation de cet état de vigilance: les neurones actifs (SP-on) et ceux au contraire inactifs (SP-off) pendant les épisodes de sommeil paradoxal. La leptine agirait vraisemblablement en activant les neurones de type SP-off, en l’occurrence les neurones sérotoninergiques du raphé et les neurones histaminergiques de l’hypothalamus postérieur. Enfin, il existe des liens entre les apnées du sommeil et la leptine, qui tendent à montrer qu’une hyperleptinémie est associée à la sévérité des troubles hypoxiques. Leptin is an hormone produced by adipose tissue, that acts at hypothalamic level to reduce appetite. This action is mediated by both an inhibitory effect on the synthesis of molecules that stimulate food consumption (such as hypocretins) and a stimulation of anoretic molecules production. In fact, impairments of leptinergic function are associated with various pathologies such as obesity. In other respects, food consumption and the metabolic state are known to impinge upon sleep. Satiety facilitates whereas hunger inhibits sleep. Leptin induces a decrease in the amounts of paradoxical sleep, and these relations would be based on the reciprocal interaction model of regulation of this sleep state: neurons that are active (PS-on) and neurons that are inactive (PS-off) during paradoxical sleep episodes. Leptin would likely act through activation of SP-off neurons, such as serotonergic ones in the Raphe nucleus and histaminergic ones in the posterior hypothalamus. Finally, relations are found between sleep apneas and leptin, which suggest that hyperleptinemia is associated with the severity of hypoxia." @default.
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• W2095296989 date "2004-09-01" @default.
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• W2095296989 title "Leptine et sommeil : des liens méconnus ?" @default.
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• W2095296989 doi "https://doi.org/10.1016/s1769-4493(04)70164-8" @default.
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