FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095305861> ?p ?o ?g. }

• W2095305861 endingPage "148" @default.
• W2095305861 startingPage "141" @default.
• W2095305861 abstract "We studied the relation between the glutathione (GSH) system and cell proliferation in a model of smooth muscle cells (SMC) derived from the thoracic aorta of 4-6-week-old (young) and 15-month-old (aged) rats. SMC from aged rats showed greater levels of total non-protein thiol compounds (T-SH), increased glutathione transferase (GST) and increased glutathione reductase (GSSG-Red) activities compared with cells from young rats. These changes were associated with an increased proliferation rate of SMC from aged rats. To evaluate the role of GSH on cell proliferation better, a specific inhibitor of gamma-glutamyl-cystein synthetase, DL-buthionine-SR-sulphoximine (BSO) was used. BSO showed a dose-dependent inhibition of cell growth, with an IC50 of 10(-4) M, after 48-72 h of incubation. Removal of BSO restored cell growth, further suggesting a link between GSH levels and vascular cell proliferation. The inhibitory effect of BSO was about two times greater on SMC from young than on SMC from aged rats. BSO showed 56% inhibition on the proliferation of SMC from young rats and 32% inhibition on SMC from aged rats (10(-4) M, 72 h of incubation). A parallel reduction of GSH levels of 38% and 19% for SMC from young and aged rats, respectively, was observed, suggesting that age-related factors may influence the involvement of GSH system in cell proliferation." @default.
• W2095305861 created "2016-06-24" @default.
• W2095305861 creator A5028922467 @default.
• W2095305861 creator A5031384463 @default.
• W2095305861 creator A5033196989 @default.
• W2095305861 creator A5061015615 @default.
• W2095305861 creator A5066251493 @default.
• W2095305861 creator A5075907570 @default.
• W2095305861 creator A5080670556 @default.
• W2095305861 creator A5084447279 @default.
• W2095305861 date "1993-05-01" @default.
• W2095305861 modified "2023-09-24" @default.
• W2095305861 title "Differences in the glutathione system of cultured aortic smooth muscle cells from young and aged rats" @default.
• W2095305861 cites W1535828429 @default.
• W2095305861 cites W1581414347 @default.
• W2095305861 cites W1932056767 @default.
• W2095305861 cites W1964789930 @default.
• W2095305861 cites W1966529358 @default.
• W2095305861 cites W1969500177 @default.
• W2095305861 cites W1974238226 @default.
• W2095305861 cites W1975980695 @default.
• W2095305861 cites W1987008982 @default.
• W2095305861 cites W2006370393 @default.
• W2095305861 cites W2023139493 @default.
• W2095305861 cites W2026610291 @default.
• W2095305861 cites W2036279769 @default.
• W2095305861 cites W2050578975 @default.
• W2095305861 cites W2051289202 @default.
• W2095305861 cites W2061755142 @default.
• W2095305861 cites W2087154637 @default.
• W2095305861 cites W2092690876 @default.
• W2095305861 cites W2110575305 @default.
• W2095305861 cites W2118556410 @default.
• W2095305861 cites W2119824831 @default.
• W2095305861 cites W2131819464 @default.
• W2095305861 cites W2147419584 @default.
• W2095305861 cites W2315512556 @default.
• W2095305861 cites W2431030371 @default.
• W2095305861 cites W4245957869 @default.
• W2095305861 cites W4293247451 @default.
• W2095305861 doi "https://doi.org/10.1016/0021-9150(93)90200-e" @default.
• W2095305861 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8102847" @default.
• W2095305861 hasPublicationYear "1993" @default.
• W2095305861 type Work @default.
• W2095305861 sameAs 2095305861 @default.
• W2095305861 citedByCount "14" @default.
• W2095305861 countsByYear W20953058612014 @default.
• W2095305861 crossrefType "journal-article" @default.
• W2095305861 hasAuthorship W2095305861A5028922467 @default.
• W2095305861 hasAuthorship W2095305861A5031384463 @default.
• W2095305861 hasAuthorship W2095305861A5033196989 @default.
• W2095305861 hasAuthorship W2095305861A5061015615 @default.
• W2095305861 hasAuthorship W2095305861A5066251493 @default.
• W2095305861 hasAuthorship W2095305861A5075907570 @default.
• W2095305861 hasAuthorship W2095305861A5080670556 @default.
• W2095305861 hasAuthorship W2095305861A5084447279 @default.
• W2095305861 hasConcept C126322002 @default.
• W2095305861 hasConcept C134018914 @default.
• W2095305861 hasConcept C1491633281 @default.
• W2095305861 hasConcept C16685009 @default.
• W2095305861 hasConcept C181199279 @default.
• W2095305861 hasConcept C185592680 @default.
• W2095305861 hasConcept C25642318 @default.
• W2095305861 hasConcept C2777476445 @default.
• W2095305861 hasConcept C2779395532 @default.
• W2095305861 hasConcept C2781324293 @default.
• W2095305861 hasConcept C2992686903 @default.
• W2095305861 hasConcept C538909803 @default.
• W2095305861 hasConcept C55493867 @default.
• W2095305861 hasConcept C62112901 @default.
• W2095305861 hasConcept C71924100 @default.
• W2095305861 hasConcept C86803240 @default.
• W2095305861 hasConceptScore W2095305861C126322002 @default.
• W2095305861 hasConceptScore W2095305861C134018914 @default.
• W2095305861 hasConceptScore W2095305861C1491633281 @default.
• W2095305861 hasConceptScore W2095305861C16685009 @default.
• W2095305861 hasConceptScore W2095305861C181199279 @default.
• W2095305861 hasConceptScore W2095305861C185592680 @default.
• W2095305861 hasConceptScore W2095305861C25642318 @default.
• W2095305861 hasConceptScore W2095305861C2777476445 @default.
• W2095305861 hasConceptScore W2095305861C2779395532 @default.
• W2095305861 hasConceptScore W2095305861C2781324293 @default.
• W2095305861 hasConceptScore W2095305861C2992686903 @default.
• W2095305861 hasConceptScore W2095305861C538909803 @default.
• W2095305861 hasConceptScore W2095305861C55493867 @default.
• W2095305861 hasConceptScore W2095305861C62112901 @default.
• W2095305861 hasConceptScore W2095305861C71924100 @default.
• W2095305861 hasConceptScore W2095305861C86803240 @default.
• W2095305861 hasIssue "2" @default.
• W2095305861 hasLocation W20953058611 @default.
• W2095305861 hasLocation W20953058612 @default.
• W2095305861 hasOpenAccess W2095305861 @default.
• W2095305861 hasPrimaryLocation W20953058611 @default.
• W2095305861 hasRelatedWork W1966695668 @default.
• W2095305861 hasRelatedWork W2012680209 @default.
• W2095305861 hasRelatedWork W2013677839 @default.
• W2095305861 hasRelatedWork W2015256044 @default.
• W2095305861 hasRelatedWork W2016251044 @default.

• next