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- W2095314259 abstract "Although obesity, dyslipidemia and insulin resistance (IR) are well known risk factors for systemic cardiovascular disease, their impact on pulmonary arterial hypertension (PAH) is unknown. The present authors’ previous studies indicate that IR may be a risk factor for PAH. The current study has investigated the prevalence of IR in PAH and explored its relationship with disease severity. Clinical data and fasting blood samples were evaluated in 81 nondiabetic PAH females. In total, 967 National Health and Nutrition Examination Surveys (NHANES) females served as controls. The fasting triglyceride to high-density lipoprotein cholesterol ratio was used as a surrogate of insulin sensitivity. While body mass index was similar in NHANES <i>versus</i> PAH females (28.6 <i>versus</i> 28.7 kg·m<sup>−2</sup>), PAH females were more likely to have IR (45.7 <i>versus</i> 21.5%) and less likely to be insulin sensitive (IS; 43.2 <i>versus</i> 57.8%). PAH females mostly (82.7%) had New York Heart Association (NYHA) class II and III symptoms. Aetiology, NYHA class, 6-min walk-distance and haemodynamics did not differ between IR and IS PAH groups. However, the presence of IR and a higher NYHA class was associated with poorer 6-months event-free survival (58 <i>versus</i> 79%). Insulin resistance appears to be more common in pulmonary arterial hypertension females than in the general population, and may be a novel risk factor or disease modifier that might impact on survival." @default.
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- W2095314259 date "2008-09-17" @default.
- W2095314259 modified "2023-10-04" @default.
- W2095314259 title "Insulin resistance in pulmonary arterial hypertension" @default.
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- W2095314259 doi "https://doi.org/10.1183/09031936.00000508" @default.
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