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- W2095314557 abstract "Introduction: Aging may impair healing and promote adverse remodeling after reperfused myocardial infarction (RMI) whereas healing-specific proteins such as secretory leucocyte protease inhibitor (SLPI), secreted protein acidic and rich in cysteine (SPARC) and osteopontin (OPN) may improve healing and remodeling after RMI. Matrix metalloproteinase (MMP)–9 and tissue inhibitor of MMP (TIMP)–3 imbalance contributes to remodeling and dysfunction after RMI. We sought to determine whether aging upregulates SLPI, SPARC, OPN, MMP–9 and cytokines tumor necrosis factor (TNF)-α and transforming growth factor (TGF)-β1 in acute RMI. Methods: We measured in vivo LV remodeling and function (echocardiography) and the ex vivo expression of regional SLPI, SPARC, OPN, MMP–9 and TIMP–3 after acute anterior RMI (90 min no-flow ischemia and 120 min reperfusion) in young (group 1) and old (group 2) dogs. Results: Compared to group 1 controls, group 2 hearts showed more severe LV remodeling and dysfunction (with lower ejection fraction, larger volumes and more diastolic dysfunction, infarct expansion and thinning) and upregulation of SLPI, SPARC, OPN and MMP–9 as well as increased MMP–9/ TIMP–3 ratio and cytokines TNF-α and TGF-β1 in the reperfused ischemic zone. Conclusion: The results suggest that upregulation of SLPI, SPARC and OPN and increased MMP–9/TIMP–3 imbalance as well as TNF-α and TGF-β1 with aging may contribute to more severe LV remodeling, dysfunction after acute RMI." @default.
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- W2095314557 date "2008-08-01" @default.
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- W2095314557 title "Aging Upregulates Healing-Specific Proteins, MMP-9 and Cytokines after Acute Reperfused Myocardial Infarction" @default.
- W2095314557 doi "https://doi.org/10.1016/j.cardfail.2008.06.117" @default.
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