FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095328142> ?p ?o ?g. }

• W2095328142 endingPage "5621" @default.
• W2095328142 startingPage "5609" @default.
• W2095328142 abstract "Retinoid X receptor (RXR) plays a crucial role in the cross talk between retinoid receptors and other hormone receptors including the orphan receptor TR3, forming different heterodimers that transduce diverse steroid/thyroid hormone signaling. Here we show that RXRalpha exhibits nucleocytoplasmic shuttling in MGC80-3 gastric cancer cells and that RXRalpha shuttling is energy-dependent through a nuclear pore complex (NPC)-mediated pathway for its import and an intact DNA binding domain-mediated pathway for its export. In the presence of its ligand 9-cis retinoic acid, RXRalpha was almost exclusively located in the cytoplasm. More importantly, we also show that RXRalpha acts as a carrier to assist translocation of TR3, which plays an important role in apoptosis. Both RXRalpha and TR3 colocalized in the nucleus; however, upon stimulation by 9-cis retinoic acid they cotranslocated to the cytoplasm and then localized in the mitochondria. TR3 export depends on RXRalpha, as in living cells GFP-TR3 alone did not result in export from the nucleus even in the presence of 9-cis retinoic acid, whereas GFP-TR3 cotransfected with RXRalpha was exported out of the nucleus in response to 9-cis retinoic acid. Moreover, specific reduction of RXRalpha levels caused by anti-sense RXRalpha abolished TR3 nuclear export. In contrast, specific knockdown of TR3 by antisense-TR3 or TR3-siRNA did not affect RXRalpha shuttling. These results indicate that RXRalpha is responsible for TR3 nucleocytoplasmic translocation, which is facilitated by the RXRalpha ligand 9-cis retinoic acid. In addition, mitochondrial TR3, but not RXRalpha, was critical for apoptosis, as TR3 mutants that were distributed in the mitochondria induced apoptosis in the presence or absence of 9-cis retinoic acid. These data reveal a novel aspect of RXRalpha function, in which it acts as a carrier for nucleocytoplasmic translocation of orphan receptors." @default.
• W2095328142 created "2016-06-24" @default.
• W2095328142 creator A5005753526 @default.
• W2095328142 creator A5030886588 @default.
• W2095328142 creator A5036614817 @default.
• W2095328142 creator A5042477637 @default.
• W2095328142 creator A5055365138 @default.
• W2095328142 creator A5059410493 @default.
• W2095328142 creator A5066824193 @default.
• W2095328142 creator A5082077159 @default.
• W2095328142 creator A5087236917 @default.
• W2095328142 date "2004-11-01" @default.
• W2095328142 modified "2023-10-16" @default.
• W2095328142 title "RXRα acts as a carrier for TR3 nuclear export in a 9-cis retinoic acid-dependent manner in gastric cancer cells" @default.
• W2095328142 cites W1577554347 @default.
• W2095328142 cites W1578055894 @default.
• W2095328142 cites W1607714362 @default.
• W2095328142 cites W1616121322 @default.
• W2095328142 cites W1968199586 @default.
• W2095328142 cites W1980655244 @default.
• W2095328142 cites W1984695968 @default.
• W2095328142 cites W1986437761 @default.
• W2095328142 cites W1987040411 @default.
• W2095328142 cites W1995754186 @default.
• W2095328142 cites W2002351432 @default.
• W2095328142 cites W2003928686 @default.
• W2095328142 cites W2009975411 @default.
• W2095328142 cites W2013995071 @default.
• W2095328142 cites W2016153572 @default.
• W2095328142 cites W2016798180 @default.
• W2095328142 cites W2017493275 @default.
• W2095328142 cites W2017719948 @default.
• W2095328142 cites W2022707915 @default.
• W2095328142 cites W2025631499 @default.
• W2095328142 cites W2026203588 @default.
• W2095328142 cites W2032785100 @default.
• W2095328142 cites W2037077714 @default.
• W2095328142 cites W2037709017 @default.
• W2095328142 cites W2044568075 @default.
• W2095328142 cites W2044768708 @default.
• W2095328142 cites W2046376456 @default.
• W2095328142 cites W2050627047 @default.
• W2095328142 cites W2058126265 @default.
• W2095328142 cites W2059624730 @default.
• W2095328142 cites W2059625963 @default.
• W2095328142 cites W2061964177 @default.
• W2095328142 cites W2063055503 @default.
• W2095328142 cites W2063205034 @default.
• W2095328142 cites W2064544547 @default.
• W2095328142 cites W2064613822 @default.
• W2095328142 cites W2072810131 @default.
• W2095328142 cites W2072931419 @default.
• W2095328142 cites W2075796826 @default.
• W2095328142 cites W2077430113 @default.
• W2095328142 cites W2078146089 @default.
• W2095328142 cites W2080080632 @default.
• W2095328142 cites W2087870421 @default.
• W2095328142 cites W2088134840 @default.
• W2095328142 cites W2096790906 @default.
• W2095328142 cites W2096855269 @default.
• W2095328142 cites W2102082802 @default.
• W2095328142 cites W2102420815 @default.
• W2095328142 cites W2103653609 @default.
• W2095328142 cites W2106925642 @default.
• W2095328142 cites W2111897372 @default.
• W2095328142 cites W2112823160 @default.
• W2095328142 cites W2114261502 @default.
• W2095328142 cites W2117346996 @default.
• W2095328142 cites W2118040139 @default.
• W2095328142 cites W2119908949 @default.
• W2095328142 cites W2131830910 @default.
• W2095328142 cites W2133201628 @default.
• W2095328142 cites W2137336327 @default.
• W2095328142 cites W2147673480 @default.
• W2095328142 cites W2149811610 @default.
• W2095328142 cites W2155085170 @default.
• W2095328142 cites W2165306451 @default.
• W2095328142 cites W2170645024 @default.
• W2095328142 cites W2171258458 @default.
• W2095328142 cites W2344038510 @default.
• W2095328142 cites W2404213927 @default.
• W2095328142 cites W2589970558 @default.
• W2095328142 cites W270887500 @default.
• W2095328142 doi "https://doi.org/10.1242/jcs.01474" @default.
• W2095328142 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15494375" @default.
• W2095328142 hasPublicationYear "2004" @default.
• W2095328142 type Work @default.
• W2095328142 sameAs 2095328142 @default.
• W2095328142 citedByCount "61" @default.
• W2095328142 countsByYear W20953281422012 @default.
• W2095328142 countsByYear W20953281422014 @default.
• W2095328142 countsByYear W20953281422015 @default.
• W2095328142 countsByYear W20953281422016 @default.
• W2095328142 countsByYear W20953281422017 @default.
• W2095328142 countsByYear W20953281422018 @default.
• W2095328142 countsByYear W20953281422019 @default.
• W2095328142 countsByYear W20953281422020 @default.
• W2095328142 countsByYear W20953281422021 @default.

• next