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- W2095330079 abstract "Protocols for islet transplantation have to take into account the diabetogenicity/islet toxicity of the immunosuppressive agents, namely corticosteroids and calcineurin inhibitors, most notably tacrolimus. The development by the Edmonton group of a sirolimus-based, steroid-free, low-tacrolimus regimen was a significant breakthrough that allowed the rate of insulin independence after islet transplantation to increase from 13% to 80% at 1 year. Drawbacks include the side effects of sirolimus and the reduction in insulin independence to 50% at 3 years, the latter being attributed to prolonged tacrolimus exposure. Currently explored alternatives to tacrolimus include cyclosporine, mycophenolate mofetil, and the novel agent FTY 720. Perspectives for the near future involve the achievement of “prope tolerance” by strategies using lymphocyte-depleting antibodies (anti-thymocyte globulin, campath-1H, hOKT3γ1 [ala,ala]), or costimulatory blockade (anti-CD154 mAbs, CTLA4-Ig)." @default.
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- W2095330079 title "Combined effect of rapamycin and FK 506 in prolongation of small bowel graft survival in the mouse" @default.
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