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- W2095333721 abstract "To determine whether neurotrophins act on functionally distinct populations of adult sensory neurons, the distributions of mRNAs for TrkA and tyrosine kinase-containing isoforms of TrkB and TrkC were determined in rat DRG neurons projecting to different peripheral targets. Whereas trkA was expressed by a very high percentage of visceral afferents, trkC was expressed frequently only in muscle afferents. Among cutaneous afferents, the size distributions for trkA- and trkC-positive cells showed little overlap. The percentages and size distributions of cells labeled for the trks argue strongly that almost all trkB-expressing cells must also express trkA or trkC. These results indicate that NGF and NT-3 act on functionally distinct populations of adult sensory neurons and suggest that a sizeable number of small DRG neurons may not respond to neurotrophins via a known Trk in the adult rat." @default.
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- W2095333721 date "1998-01-01" @default.
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- W2095333721 title "The neuroprotective effect of NGF against glutamate neurotoxicity is mediated by P75 neurotrophin receptor in cortical cultures" @default.
- W2095333721 doi "https://doi.org/10.1016/s0168-0102(98)82415-2" @default.
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