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• W2095337675 endingPage "113" @default.
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• W2095337675 abstract "Many evidence suggest that metabotropic glutamate receptors (mGluRs) may modulate glutamatergic transmission, hence, these receptors are regarded as potential targets for neuroprotective drugs. Since group III mGlu receptor agonists are known to reduce glutamatergic transmission by inhibiting glutamate release, we decided to investigate the neuroprotective potential of the group III mGlu receptor agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid (ACPT-I) against kainate (KA)-induced excitotoxicity in vitro and in vivo. In primary neuronal cell cultures ACPT-I (1–200 μM), applied 30 min–3 h after starting the exposure to KA (150 μM), significantly attenuated the KA-induced LDH release, increased cell viability, and inhibited caspase-3 activity both in cortical and hippocampal cell cultures. The effects were dose-, time- and structure-dependent. The neuroprotective effects of ACPT-I were reversed by (RS)-alpha-cyclopropyl-4-phosphonophenyl glycine, a group III mGluR antagonist. In the in vivo studies, KA (2.5 nmol/1 μl) was unilaterally injected into the rat dorsal CA1 hippocampal region and the size of degeneration was examined by stereological counting of surviving neurons in the CA pyramidal layer. It was found that ACPT-I (7.5 or 15 nmol/1 μl), injected into the dorsal hippocampus 30 min, 1 or 3 h after KA in dose-dependent manner prevented the KA-induced neuronal damage. Moreover, in vivo microdialysis studies in the rat hippocampus showed that ACPT-I (200 μM) given simultaneously with KA (50 μM) significantly diminished the KA-induced glutamate release in the hippocampus. This mechanism seems to play a role in mediating the neuroprotective effect of ACPT-I." @default.
• W2095337675 created "2016-06-24" @default.
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• W2095337675 date "2014-01-09" @default.
• W2095337675 modified "2023-10-16" @default.
• W2095337675 title "Group III mGlu Receptor Agonist, ACPT-I, Exerts Potential Neuroprotective Effects In Vitro and In Vivo" @default.
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• W2095337675 cites W1564717701 @default.
• W2095337675 cites W1595843790 @default.
• W2095337675 cites W1600525795 @default.
• W2095337675 cites W1614343476 @default.
• W2095337675 cites W1854163003 @default.
• W2095337675 cites W1936828440 @default.
• W2095337675 cites W1964248646 @default.
• W2095337675 cites W1965494865 @default.
• W2095337675 cites W1967255770 @default.
• W2095337675 cites W1971474634 @default.
• W2095337675 cites W1971602384 @default.
• W2095337675 cites W1974619729 @default.
• W2095337675 cites W1974661780 @default.
• W2095337675 cites W1978346344 @default.
• W2095337675 cites W1983050224 @default.
• W2095337675 cites W1990909663 @default.
• W2095337675 cites W1991202463 @default.
• W2095337675 cites W1991542726 @default.
• W2095337675 cites W1992177920 @default.
• W2095337675 cites W1995387616 @default.
• W2095337675 cites W1996381158 @default.
• W2095337675 cites W1999295475 @default.
• W2095337675 cites W2001034857 @default.
• W2095337675 cites W2003066583 @default.
• W2095337675 cites W2005127919 @default.
• W2095337675 cites W2007243541 @default.
• W2095337675 cites W2007417518 @default.
• W2095337675 cites W2010395737 @default.
• W2095337675 cites W2016311787 @default.
• W2095337675 cites W2021029707 @default.
• W2095337675 cites W2022567291 @default.
• W2095337675 cites W2026655554 @default.
• W2095337675 cites W2028288155 @default.
• W2095337675 cites W2033918548 @default.
• W2095337675 cites W2035135723 @default.
• W2095337675 cites W2037337146 @default.
• W2095337675 cites W2038644671 @default.
• W2095337675 cites W2041098374 @default.
• W2095337675 cites W2043166209 @default.
• W2095337675 cites W2045530138 @default.
• W2095337675 cites W2045546840 @default.
• W2095337675 cites W2057528850 @default.
• W2095337675 cites W2057776188 @default.
• W2095337675 cites W2061301420 @default.
• W2095337675 cites W2061464288 @default.
• W2095337675 cites W2065605195 @default.
• W2095337675 cites W2067317040 @default.
• W2095337675 cites W2067526881 @default.
• W2095337675 cites W2067795636 @default.
• W2095337675 cites W2071955212 @default.
• W2095337675 cites W2072034156 @default.
• W2095337675 cites W2072729793 @default.
• W2095337675 cites W2074056751 @default.
• W2095337675 cites W2074742153 @default.
• W2095337675 cites W2077326004 @default.
• W2095337675 cites W2077497516 @default.
• W2095337675 cites W2086614619 @default.
• W2095337675 cites W2088444176 @default.
• W2095337675 cites W2092384816 @default.
• W2095337675 cites W2093440950 @default.
• W2095337675 cites W2100503686 @default.
• W2095337675 cites W2105951530 @default.
• W2095337675 cites W2106042714 @default.
• W2095337675 cites W2110241817 @default.
• W2095337675 cites W2119841109 @default.
• W2095337675 cites W2127778297 @default.
• W2095337675 cites W2132680839 @default.
• W2095337675 cites W2134289201 @default.
• W2095337675 cites W2151628789 @default.
• W2095337675 cites W2158879871 @default.
• W2095337675 cites W2164484142 @default.
• W2095337675 cites W2318994705 @default.
• W2095337675 cites W2951764089 @default.
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• W2095337675 doi "https://doi.org/10.1007/s12640-013-9455-7" @default.
• W2095337675 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4035549" @default.
• W2095337675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24402869" @default.
• W2095337675 hasPublicationYear "2014" @default.
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