FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095339919> ?p ?o ?g. }

• W2095339919 endingPage "120" @default.
• W2095339919 startingPage "109" @default.
• W2095339919 abstract "After traumatic spinal cord injury, functional deficits increase as axons die back from the center of the lesion and the glial scar forms. Axonal dieback occurs in two phases: an initial axon intrinsic stage that occurs over the first several hours and a secondary phase which takes place over the first few weeks after injury. Here, we examine the secondary phase, which is marked by infiltration of macrophages. Using powerful time-lapse multi-photon imaging, we captured images of interactions between Cx3cr1+/GFP macrophages and microglia and Thy-1YFP axons in a mouse dorsal column crush spinal cord injury model. Over the first few weeks after injury, axonal retraction bulbs within the lesion are static except when axonal fragments are lost by a blebbing mechanism in response to physical contact followed by phagocytosis by mobile Cx3Cr1+/GFP cells. Utilizing a radiation chimera model to distinguish marrow-derived cells from radio-resistant CNS-resident microglia, we determined that the vast majority of accumulated cells in the lesion are derived from the blood and only these are associated with axonal damage. Interestingly, CNS-resident Cx3Cr1+/GFP microglia did not increasingly accumulate nor participate in neuronal destruction in the lesion during this time period. Additionally, we found that the blood-derived cells consisted mainly of singly labeled Ccr2+/RFP macrophages, singly labeled Cx3Cr1+/GFP macrophages and a small population of double-labeled cells. Since all axon destructive events were seen in contact with a Cx3Cr1+/GFP cell, we infer that the CCR2 single positive subset is likely not robustly involved in axonal dieback. Finally, in our model, deletion of CCR2, a chemokine receptor, did not alter the position of axons after dieback. Understanding the in vivo cellular interactions involved in secondary axonal injury may lead to clinical treatment candidates involving modulation of destructive infiltrating blood monocytes." @default.
• W2095339919 created "2016-06-24" @default.
• W2095339919 creator A5001997941 @default.
• W2095339919 creator A5003228171 @default.
• W2095339919 creator A5009957181 @default.
• W2095339919 creator A5022587441 @default.
• W2095339919 creator A5025536959 @default.
• W2095339919 creator A5034732141 @default.
• W2095339919 creator A5045643100 @default.
• W2095339919 creator A5059056583 @default.
• W2095339919 date "2014-04-01" @default.
• W2095339919 modified "2023-10-15" @default.
• W2095339919 title "High-resolution intravital imaging reveals that blood-derived macrophages but not resident microglia facilitate secondary axonal dieback in traumatic spinal cord injury" @default.
• W2095339919 cites W1611449349 @default.
• W2095339919 cites W1974172728 @default.
• W2095339919 cites W1983712592 @default.
• W2095339919 cites W1993677761 @default.
• W2095339919 cites W1996199386 @default.
• W2095339919 cites W1999419270 @default.
• W2095339919 cites W1999952543 @default.
• W2095339919 cites W2000814289 @default.
• W2095339919 cites W2001101139 @default.
• W2095339919 cites W2003981301 @default.
• W2095339919 cites W2006517495 @default.
• W2095339919 cites W2018306768 @default.
• W2095339919 cites W2023053568 @default.
• W2095339919 cites W2026578487 @default.
• W2095339919 cites W2031325676 @default.
• W2095339919 cites W2033617297 @default.
• W2095339919 cites W2034597638 @default.
• W2095339919 cites W2042991032 @default.
• W2095339919 cites W2043930451 @default.
• W2095339919 cites W2053084751 @default.
• W2095339919 cites W2054190000 @default.
• W2095339919 cites W2059028717 @default.
• W2095339919 cites W2063520340 @default.
• W2095339919 cites W2068455373 @default.
• W2095339919 cites W2068790240 @default.
• W2095339919 cites W2077918706 @default.
• W2095339919 cites W2081476175 @default.
• W2095339919 cites W2090012338 @default.
• W2095339919 cites W2091998173 @default.
• W2095339919 cites W2094008621 @default.
• W2095339919 cites W2094660330 @default.
• W2095339919 cites W2098853912 @default.
• W2095339919 cites W2101689759 @default.
• W2095339919 cites W2104003768 @default.
• W2095339919 cites W2111253543 @default.
• W2095339919 cites W2112961986 @default.
• W2095339919 cites W2113107925 @default.
• W2095339919 cites W2115855931 @default.
• W2095339919 cites W2122828560 @default.
• W2095339919 cites W2124775506 @default.
• W2095339919 cites W2127278809 @default.
• W2095339919 cites W2127810309 @default.
• W2095339919 cites W2130529018 @default.
• W2095339919 cites W2132924600 @default.
• W2095339919 cites W2145013402 @default.
• W2095339919 cites W2145790424 @default.
• W2095339919 cites W2148898943 @default.
• W2095339919 cites W2151417786 @default.
• W2095339919 cites W2151571528 @default.
• W2095339919 cites W2153206087 @default.
• W2095339919 cites W2153406260 @default.
• W2095339919 cites W2159775713 @default.
• W2095339919 cites W2159888487 @default.
• W2095339919 cites W2161057248 @default.
• W2095339919 cites W2161456562 @default.
• W2095339919 cites W52558577 @default.
• W2095339919 cites W73990037 @default.
• W2095339919 doi "https://doi.org/10.1016/j.expneurol.2014.01.013" @default.
• W2095339919 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3954731" @default.
• W2095339919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24468477" @default.
• W2095339919 hasPublicationYear "2014" @default.
• W2095339919 type Work @default.
• W2095339919 sameAs 2095339919 @default.
• W2095339919 citedByCount "170" @default.
• W2095339919 countsByYear W20953399192014 @default.
• W2095339919 countsByYear W20953399192015 @default.
• W2095339919 countsByYear W20953399192016 @default.
• W2095339919 countsByYear W20953399192017 @default.
• W2095339919 countsByYear W20953399192018 @default.
• W2095339919 countsByYear W20953399192019 @default.
• W2095339919 countsByYear W20953399192020 @default.
• W2095339919 countsByYear W20953399192021 @default.
• W2095339919 countsByYear W20953399192022 @default.
• W2095339919 countsByYear W20953399192023 @default.
• W2095339919 crossrefType "journal-article" @default.
• W2095339919 hasAuthorship W2095339919A5001997941 @default.
• W2095339919 hasAuthorship W2095339919A5003228171 @default.
• W2095339919 hasAuthorship W2095339919A5009957181 @default.
• W2095339919 hasAuthorship W2095339919A5022587441 @default.
• W2095339919 hasAuthorship W2095339919A5025536959 @default.
• W2095339919 hasAuthorship W2095339919A5034732141 @default.
• W2095339919 hasAuthorship W2095339919A5045643100 @default.
• W2095339919 hasAuthorship W2095339919A5059056583 @default.
• W2095339919 hasBestOaLocation W20953399191 @default.
• W2095339919 hasConcept C12823836 @default.

• next