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- W2095366494 abstract "Diffusion in macromolecular solutions and networks is a topic of vast importance in many fields related to medical devices, biotechnology, tissue engineering, or drug delivery. Thus, effort has been devoted to developing techniques for measuring and models for predicting diffusion in macromolecular solutions and networks. However, very few techniques are capable of probing diffusion in situ, real time, and non-invasively and while many models of diffusion exist, all of them have their drawbacks. Ideally a model starting from basic physics using rigorous mathematical principles should be developed that is also supported by experimental findings.First, we present measurements of probe diffusion in polymeric solutions conducted by Fluorescence Correlation Spectroscopy (FCS). We have shown that FCS is an excellent tool for real time, non-invasive study of diffusion in complex media. Here, we present studies identifying several transport regimes – without interaction, and with interaction between the probe and the macromolecule. In the latter regime the nature of the interaction determines the specifics of the sub-diffusional process. We discuss two interaction examples – one where a “permanent” polymer/probe complex is formed, and one where ionic interaction is responsible for the decrease in probe diffusivity.We have also developed a novel mathematical model based on homogenization theory, to describe the effective diffusion process. To the best of our knowledge, homogenization theory, has not been used previously to describe the diffusion of probes in macromolecular solutions. The homogenization theory was confirmed by Monte Carlo simulations. An excellent agreement between the homogenization theory and Monte Carlo simulations as well as comparison to experimental data provided evidence for the utility of the homogenization theory for predicting diffusion in macromolecular solutions." @default.
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- W2095366494 date "2015-01-01" @default.
- W2095366494 modified "2023-09-29" @default.
- W2095366494 title "Experimental and Theoretical Approaches to the Study of Probe Diffusion in Macromolecular Solutions" @default.
- W2095366494 doi "https://doi.org/10.1016/j.bpj.2014.11.878" @default.
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