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• W2095370504 startingPage "741" @default.
• W2095370504 abstract "Most mammalian cells do not divide indefinitely, owing to a process termed replicative senescence. In human cells, replicative senescence is caused by telomere shortening, but murine cells senesce despite having long stable telomeres1. Here, we show that the phenotypes of senescent human fibroblasts and mouse embryonic fibroblasts (MEFs) differ under standard culture conditions, which include 20% oxygen. MEFs did not senesce in physiological (3%) oxygen levels, but underwent a spontaneous event that allowed indefinite proliferation in 20% oxygen. The proliferation and cytogenetic profiles of DNA repair-deficient MEFs suggested that DNA damage limits MEF proliferation in 20% oxygen. Indeed, MEFs accumulated more DNA damage in 20% oxygen than 3% oxygen, and more damage than human fibroblasts in 20% oxygen. Our results identify oxygen sensitivity as a critical difference between mouse and human cells, explaining their proliferative differences in culture, and possibly their different rates of cancer and ageing." @default.
• W2095370504 created "2016-06-24" @default.
• W2095370504 creator A5000443472 @default.
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• W2095370504 date "2003-07-13" @default.
• W2095370504 modified "2023-10-17" @default.
• W2095370504 title "Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts" @default.
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• W2095370504 doi "https://doi.org/10.1038/ncb1024" @default.
• W2095370504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4940195" @default.
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• W2095370504 hasPublicationYear "2003" @default.
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