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- W2095374351 abstract "To investigate the biocompatibility of the new single-needle (SN) technique of the AS 104 blood cell separator, we analysed coagulation, complement and haemolysis parameters prior to, during and after five plateletphereses. The data were compared with results of the same parameters from identical donors in the dual-needle (DN) procedure. The analysis of bilirubin, lactate dehydrogenase (LDH), hydroxybutyrate dehydrogenase (HBDH) and haptoglobin showed that there was no relevant haemolysis. However, changes of the concentration of the coagulation factors XII and XI indicated an activation of coagulation. This was confirmed by an increase of the thrombin antithrombin (TAT) III complex during apheresis. Comparison of the platelet products showed no significant differences. Glucose concentration was 332 ± 14 mg/dL in the SN and 312 ± 32 mg/dL in the DN procedure, respectively. Lactate level was 3.2 ± 0.6 mmol/L in the SN and 3.3 ± 0.6 in the DN technique, respectively. Levels of complement activation markers were not statistically different. Leukocyte contamination was statistically higher in the SN procedure." @default.
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- W2095374351 title "Biocompatibility studies of the single and dual-needle procedure in plateletpheresis with the fresenius AS 104 blood cell separator" @default.
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