Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095376387> ?p ?o ?g. }
- W2095376387 endingPage "e0128205" @default.
- W2095376387 startingPage "e0128205" @default.
- W2095376387 abstract "Reactive oxygen and nitrogen species produced by cold atmospheric plasma (CAP) are considered to be the most important species for biomedical applications, including cancer treatment. However, it is not known which species exert the greatest biological effects, and the nature of their interactions with tumor cells remains ill-defined. These questions were addressed in the present study by exposing human mesenchymal stromal and LP-1 cells to reactive oxygen and nitrogen species produced by CAP and evaluating cell viability. Superoxide anion (O2−) and hydrogen peroxide (H2O2) were the two major species present in plasma, but their respective concentrations were not sufficient to cause cell death when used in isolation; however, in the presence of iron, both species enhanced the cell death-inducing effects of plasma. We propose that iron containing proteins in cells catalyze O2− and H2O2 into the highly reactive OH radical that can induce cell death. The results demonstrate how reactive species are transferred to liquid and converted into the OH radical to mediate cytotoxicity and provide mechanistic insight into the molecular mechanisms underlying tumor cell death by plasma treatment." @default.
- W2095376387 created "2016-06-24" @default.
- W2095376387 creator A5007472959 @default.
- W2095376387 creator A5030839263 @default.
- W2095376387 creator A5038503071 @default.
- W2095376387 creator A5040640447 @default.
- W2095376387 creator A5062432526 @default.
- W2095376387 creator A5063253432 @default.
- W2095376387 creator A5064194882 @default.
- W2095376387 creator A5068161146 @default.
- W2095376387 creator A5079198045 @default.
- W2095376387 date "2015-06-05" @default.
- W2095376387 modified "2023-10-12" @default.
- W2095376387 title "In Situ OH Generation from O2− and H2O2 Plays a Critical Role in Plasma-Induced Cell Death" @default.
- W2095376387 cites W1523213544 @default.
- W2095376387 cites W1537944915 @default.
- W2095376387 cites W1543687525 @default.
- W2095376387 cites W1556055954 @default.
- W2095376387 cites W1927549009 @default.
- W2095376387 cites W1970543977 @default.
- W2095376387 cites W1978624575 @default.
- W2095376387 cites W1979986387 @default.
- W2095376387 cites W1980291173 @default.
- W2095376387 cites W1984258788 @default.
- W2095376387 cites W1990549321 @default.
- W2095376387 cites W1994220134 @default.
- W2095376387 cites W2003189059 @default.
- W2095376387 cites W2009761182 @default.
- W2095376387 cites W2010681884 @default.
- W2095376387 cites W2018252351 @default.
- W2095376387 cites W2041019415 @default.
- W2095376387 cites W2042904461 @default.
- W2095376387 cites W2066193957 @default.
- W2095376387 cites W2083079129 @default.
- W2095376387 cites W2086854995 @default.
- W2095376387 cites W2096869961 @default.
- W2095376387 cites W2106576504 @default.
- W2095376387 cites W2121463940 @default.
- W2095376387 cites W2126473492 @default.
- W2095376387 cites W2127426481 @default.
- W2095376387 cites W2135271618 @default.
- W2095376387 cites W2151850710 @default.
- W2095376387 cites W2159713683 @default.
- W2095376387 cites W2160487921 @default.
- W2095376387 cites W2162783662 @default.
- W2095376387 cites W2167347711 @default.
- W2095376387 cites W2169327432 @default.
- W2095376387 cites W2209359394 @default.
- W2095376387 cites W2398992476 @default.
- W2095376387 cites W2415859941 @default.
- W2095376387 cites W2985027918 @default.
- W2095376387 cites W3175372969 @default.
- W2095376387 cites W4300903703 @default.
- W2095376387 doi "https://doi.org/10.1371/journal.pone.0128205" @default.
- W2095376387 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4457797" @default.
- W2095376387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26046915" @default.
- W2095376387 hasPublicationYear "2015" @default.
- W2095376387 type Work @default.
- W2095376387 sameAs 2095376387 @default.
- W2095376387 citedByCount "118" @default.
- W2095376387 countsByYear W20953763872015 @default.
- W2095376387 countsByYear W20953763872016 @default.
- W2095376387 countsByYear W20953763872017 @default.
- W2095376387 countsByYear W20953763872018 @default.
- W2095376387 countsByYear W20953763872019 @default.
- W2095376387 countsByYear W20953763872020 @default.
- W2095376387 countsByYear W20953763872021 @default.
- W2095376387 countsByYear W20953763872022 @default.
- W2095376387 countsByYear W20953763872023 @default.
- W2095376387 crossrefType "journal-article" @default.
- W2095376387 hasAuthorship W2095376387A5007472959 @default.
- W2095376387 hasAuthorship W2095376387A5030839263 @default.
- W2095376387 hasAuthorship W2095376387A5038503071 @default.
- W2095376387 hasAuthorship W2095376387A5040640447 @default.
- W2095376387 hasAuthorship W2095376387A5062432526 @default.
- W2095376387 hasAuthorship W2095376387A5063253432 @default.
- W2095376387 hasAuthorship W2095376387A5064194882 @default.
- W2095376387 hasAuthorship W2095376387A5068161146 @default.
- W2095376387 hasAuthorship W2095376387A5079198045 @default.
- W2095376387 hasBestOaLocation W20953763871 @default.
- W2095376387 hasConcept C109316439 @default.
- W2095376387 hasConcept C1491633281 @default.
- W2095376387 hasConcept C181199279 @default.
- W2095376387 hasConcept C185592680 @default.
- W2095376387 hasConcept C190283241 @default.
- W2095376387 hasConcept C202751555 @default.
- W2095376387 hasConcept C2779525624 @default.
- W2095376387 hasConcept C2780795997 @default.
- W2095376387 hasConcept C31573885 @default.
- W2095376387 hasConcept C48349386 @default.
- W2095376387 hasConcept C53227056 @default.
- W2095376387 hasConcept C533411734 @default.
- W2095376387 hasConcept C55493867 @default.
- W2095376387 hasConcept C86803240 @default.
- W2095376387 hasConcept C95444343 @default.
- W2095376387 hasConceptScore W2095376387C109316439 @default.
- W2095376387 hasConceptScore W2095376387C1491633281 @default.
- W2095376387 hasConceptScore W2095376387C181199279 @default.