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- W2095383876 abstract "ABSTRACT Cell-to-cell transmission of human immunodeficiency virus type 1 (HIV-1) occurs via a virological synapse (VS), a tight cell-cell junction formed between HIV-infected cells and target cells in which the HIV-1-infected cell polarizes and releases virions toward the noninfected target cell in a gp120- and intercellular adhesion molecule 1 (ICAM-1)-dependent process. The response of the target cell has been less studied. We utilized supported planar bilayers presenting gp120 and ICAM-1 as a reductionist model for the infected-cell membrane and investigated its effect on the target CD4 T cell. This study shows that HIV-1 gp120 interaction with its receptors is initially organized into microclusters that undergo F-actin-dependent consolidation into a central supramolecular activation complex (cSMAC). Src kinases are active in both gp120 microclusters and in the VS cSMAC. The early T-cell receptor (TCR) signaling machinery is partially activated at the VS, and signaling does not propagate to trigger Ca 2+ elevation or increase CD69 expression. However, these partial TCR signals act locally to create an F-actin-depleted zone. We propose a model in which the F-actin-depleted zone formed within the target CD4 T cell enhances the reception of virions by releasing the physical barrier for HIV-1 entry and facilitating postentry events." @default.
- W2095383876 created "2016-06-24" @default.
- W2095383876 creator A5038604401 @default.
- W2095383876 creator A5041772105 @default.
- W2095383876 creator A5071352515 @default.
- W2095383876 creator A5080281376 @default.
- W2095383876 date "2009-11-01" @default.
- W2095383876 modified "2023-10-16" @default.
- W2095383876 title "Human Immunodeficiency Virus Type 1 Envelope gp120-Induced Partial T-Cell Receptor Signaling Creates an F-Actin-Depleted Zone in the Virological Synapse" @default.
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- W2095383876 doi "https://doi.org/10.1128/jvi.01440-09" @default.
- W2095383876 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2772796" @default.
- W2095383876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19710135" @default.
- W2095383876 hasPublicationYear "2009" @default.
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