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- W2095384773 abstract "Background: Currently, there are no available effective preventative or adjunctive agents to alleviate symptoms of chemotherapy-induced mucositis. This is compounded by the absence of a recognized and validated non-invasive biomarker to assess gut function. This study investigated the effects of orally ingested Streptococcus thermophilus (TH-4) on chemotherapy-induced small intestinal damage in rats using the non-invasive 13C-sucrose breath test (SBT). Methods: Gastrointestinal damage was induced in 27 female dark agouti rats (148 ± 1g) with MTX (1.5 mg/kg; i.m.). Rats received MTX or saline at 0 h; with daily treatment of: TH-4 at doses of 109 (high), 108 (low) cfu/mL, or skim milk (vehicle), 48 h pre and 96 h post-MTX. The non-invasive 13C-sucrose breath test (SBT) was conducted at -24, 24 and 96 h post-MTX to monitor gut function. At sacrifice, small intestinal tissues were collected for determinations of sucrase activity, myeloperoxidase (MPO) activity and histological assessment. Results: MTX + vehicle and MTX + low TH-4-treated rats produced significantly lower SBT and sucrase activity results compared to saline controls (p < 0.001). In contrast, MTX + high TH-4 treatment showed no significant differences in the SBT compared to saline controls, and the SBT results were significantly higher compared to MTX + vehicle and MTX + low TH-4 (p < 0.05). MPO levels were significantly elevated (p < 0.05) in MTX + vehicle and MTX + low TH-4, but not following MTX + high TH-4 treatment, compared to saline controls. This was further confirmed by histological analyses. Conclusion: Oral ingestion of TH-4 at 109 cfu/mL is capable of partially attenuating small bowel damage in rats. The non-invasive SBT is a useful technique to longitudinally assess the efficacy of treatments or interventions for small bowel disease." @default.
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- W2095384773 date "2006-06-01" @default.
- W2095384773 modified "2023-09-27" @default.
- W2095384773 title "Oral ingestion of streptococcus thermophilus diminishes severity of small intestinal mucositis in methotrexate treated rats" @default.
- W2095384773 doi "https://doi.org/10.4161/cbt.5.6.2659" @default.
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