FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095387359> ?p ?o ?g. }

• W2095387359 endingPage "2304" @default.
• W2095387359 startingPage "2290" @default.
• W2095387359 abstract "Chronic viral infections lead to CD8+ T-cell exhaustion, characterized by impaired cytokine secretion and loss of proliferative capacity. While viral load and T-cell dysfunction correlate, it is currently unclear whether the quality of a cell type presenting antigen determines the degree of T-cell exhaustion or if the overall amount of antigen recognized by T cells promotes exhaustion. We found that chronic lymphocytic chorio-meningitis virus infection led to decreased CD8+ T-cell exhaustion in DC-MHC class I (MHCI) mice, in which CD8+ T cells can only recognize antigen on DCs. However, this increase in CD8+ T-cell function came at the expense of fatal immunopathology. Additional antigen recognition on nonhematopoietic cells in DC-MHCI mice promoted T-cell exhaustion and avoidance of immunopathology. Likewise, increased numbers of antigen-expressing hematopoietic cells, as well as a selective elevation of the number of DCs as the only cell type presenting antigen in DC-MHCI mice, resulted in compromised T-cell function. These results favor a scenario in which the overall amount of antigen exposure, rather than the type of cell engaging with virus-specific CD8+ T cells, is responsible for their functional exhaustion. Furthermore, exhaustion of virus-specific CD8+ T cells leads to avoidance of life-threatening immunopathology." @default.
• W2095387359 created "2016-06-24" @default.
• W2095387359 creator A5008537578 @default.
• W2095387359 creator A5025632995 @default.
• W2095387359 creator A5033052106 @default.
• W2095387359 date "2012-08-06" @default.
• W2095387359 modified "2023-09-26" @default.
• W2095387359 title "Antigen amount dictates CD8+T-cell exhaustion during chronic viral infection irrespective of the type of antigen presenting cell" @default.
• W2095387359 cites W1544285519 @default.
• W2095387359 cites W1568150013 @default.
• W2095387359 cites W1637013412 @default.
• W2095387359 cites W1907062065 @default.
• W2095387359 cites W1945827894 @default.
• W2095387359 cites W1949204310 @default.
• W2095387359 cites W1970785321 @default.
• W2095387359 cites W1973491977 @default.
• W2095387359 cites W1977629382 @default.
• W2095387359 cites W1979810161 @default.
• W2095387359 cites W1981318710 @default.
• W2095387359 cites W1993263603 @default.
• W2095387359 cites W1994257755 @default.
• W2095387359 cites W2006593948 @default.
• W2095387359 cites W2009905888 @default.
• W2095387359 cites W2015200774 @default.
• W2095387359 cites W2019969899 @default.
• W2095387359 cites W2021904843 @default.
• W2095387359 cites W2027265343 @default.
• W2095387359 cites W2037415461 @default.
• W2095387359 cites W2050287929 @default.
• W2095387359 cites W2050466666 @default.
• W2095387359 cites W2053677639 @default.
• W2095387359 cites W2059428652 @default.
• W2095387359 cites W2064706357 @default.
• W2095387359 cites W2066118264 @default.
• W2095387359 cites W2067069532 @default.
• W2095387359 cites W2067301876 @default.
• W2095387359 cites W2067758651 @default.
• W2095387359 cites W2068200417 @default.
• W2095387359 cites W2073449362 @default.
• W2095387359 cites W2076723714 @default.
• W2095387359 cites W2082008999 @default.
• W2095387359 cites W2083331853 @default.
• W2095387359 cites W2084961593 @default.
• W2095387359 cites W2096569588 @default.
• W2095387359 cites W2097855813 @default.
• W2095387359 cites W2104966044 @default.
• W2095387359 cites W2110931762 @default.
• W2095387359 cites W2115425082 @default.
• W2095387359 cites W2115624659 @default.
• W2095387359 cites W2119896120 @default.
• W2095387359 cites W2121327992 @default.
• W2095387359 cites W2138205821 @default.
• W2095387359 cites W2138591388 @default.
• W2095387359 cites W2147776994 @default.
• W2095387359 cites W2149533732 @default.
• W2095387359 cites W2150361947 @default.
• W2095387359 cites W2150492554 @default.
• W2095387359 cites W2152923082 @default.
• W2095387359 cites W2153047529 @default.
• W2095387359 cites W2155025120 @default.
• W2095387359 cites W2159124392 @default.
• W2095387359 cites W2163001100 @default.
• W2095387359 cites W2164081767 @default.
• W2095387359 cites W992974879 @default.
• W2095387359 doi "https://doi.org/10.1002/eji.201142275" @default.
• W2095387359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22653665" @default.
• W2095387359 hasPublicationYear "2012" @default.
• W2095387359 type Work @default.
• W2095387359 sameAs 2095387359 @default.
• W2095387359 citedByCount "48" @default.
• W2095387359 countsByYear W20953873592012 @default.
• W2095387359 countsByYear W20953873592013 @default.
• W2095387359 countsByYear W20953873592014 @default.
• W2095387359 countsByYear W20953873592015 @default.
• W2095387359 countsByYear W20953873592016 @default.
• W2095387359 countsByYear W20953873592017 @default.
• W2095387359 countsByYear W20953873592018 @default.
• W2095387359 countsByYear W20953873592019 @default.
• W2095387359 countsByYear W20953873592020 @default.
• W2095387359 countsByYear W20953873592021 @default.
• W2095387359 countsByYear W20953873592022 @default.
• W2095387359 countsByYear W20953873592023 @default.
• W2095387359 crossrefType "journal-article" @default.
• W2095387359 hasAuthorship W2095387359A5008537578 @default.
• W2095387359 hasAuthorship W2095387359A5025632995 @default.
• W2095387359 hasAuthorship W2095387359A5033052106 @default.
• W2095387359 hasBestOaLocation W20953873591 @default.
• W2095387359 hasConcept C147483822 @default.
• W2095387359 hasConcept C154317977 @default.
• W2095387359 hasConcept C167672396 @default.
• W2095387359 hasConcept C202751555 @default.
• W2095387359 hasConcept C203014093 @default.
• W2095387359 hasConcept C207936829 @default.
• W2095387359 hasConcept C2776090121 @default.
• W2095387359 hasConcept C55493867 @default.
• W2095387359 hasConcept C67662055 @default.
• W2095387359 hasConcept C83464605 @default.
• W2095387359 hasConcept C86803240 @default.

• next