Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095388748> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2095388748 endingPage "93" @default.
- W2095388748 startingPage "86" @default.
- W2095388748 abstract "Clostridium perfringens is a common cause of the fatal disease gas gangrene (myonecrosis). Established gas gangrene is notable for a profound absence of neutrophils and monocytic cells (phagocytes), and it has been suggested that the bactericidal activities of these cells play an insignificant role in controlling the progression of the infection. However, large inocula of bacteria are needed to establish an infection in experimental animals, suggesting phagocytes may play a role in inhibiting the initiation of gangrene. Examination of tissue sections of mice infected with a lethal (1 x 10(9)) or sublethal (1 x 10(6)) inoculum of C. perfringens revealed that phagocyte infiltration in the first 3 h postinfection was inhibited with a lethal dose but not with a sublethal dose, indicating that exclusion of phagocytes begins very early in the infection cycle. Experiments in which mice were depleted of either circulating monocytes or neutrophils before infection with C. perfringens showed that monocytes play a role in inhibiting the onset of gas gangrene at intermediate inocula but, although neutrophils can slow the onset of the infection, they are not protective. These results suggest that treatments designed to increase monocyte infiltration and activate macrophages may lead to increased resistance to the initiation of gas gangrene." @default.
- W2095388748 created "2016-06-24" @default.
- W2095388748 creator A5013597460 @default.
- W2095388748 creator A5024301494 @default.
- W2095388748 creator A5031777357 @default.
- W2095388748 creator A5035159636 @default.
- W2095388748 date "2007-06-01" @default.
- W2095388748 modified "2023-09-27" @default.
- W2095388748 title "The role of neutrophils and monocytic cells in controlling the initiation of<i>Clostridium perfringens</i>gas gangrene" @default.
- W2095388748 cites W102752527 @default.
- W2095388748 cites W1965186407 @default.
- W2095388748 cites W1968014693 @default.
- W2095388748 cites W2027830088 @default.
- W2095388748 cites W2074182306 @default.
- W2095388748 cites W2129278645 @default.
- W2095388748 cites W2138941955 @default.
- W2095388748 cites W2149167841 @default.
- W2095388748 cites W2483318262 @default.
- W2095388748 cites W25441393 @default.
- W2095388748 doi "https://doi.org/10.1111/j.1574-695x.2007.00235.x" @default.
- W2095388748 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17428305" @default.
- W2095388748 hasPublicationYear "2007" @default.
- W2095388748 type Work @default.
- W2095388748 sameAs 2095388748 @default.
- W2095388748 citedByCount "13" @default.
- W2095388748 countsByYear W20953887482012 @default.
- W2095388748 countsByYear W20953887482013 @default.
- W2095388748 countsByYear W20953887482014 @default.
- W2095388748 countsByYear W20953887482015 @default.
- W2095388748 countsByYear W20953887482016 @default.
- W2095388748 countsByYear W20953887482019 @default.
- W2095388748 countsByYear W20953887482022 @default.
- W2095388748 countsByYear W20953887482023 @default.
- W2095388748 crossrefType "journal-article" @default.
- W2095388748 hasAuthorship W2095388748A5013597460 @default.
- W2095388748 hasAuthorship W2095388748A5024301494 @default.
- W2095388748 hasAuthorship W2095388748A5031777357 @default.
- W2095388748 hasAuthorship W2095388748A5035159636 @default.
- W2095388748 hasBestOaLocation W20953887481 @default.
- W2095388748 hasConcept C121332964 @default.
- W2095388748 hasConcept C142724271 @default.
- W2095388748 hasConcept C153400128 @default.
- W2095388748 hasConcept C160448771 @default.
- W2095388748 hasConcept C203014093 @default.
- W2095388748 hasConcept C2775959528 @default.
- W2095388748 hasConcept C2776626339 @default.
- W2095388748 hasConcept C2777700362 @default.
- W2095388748 hasConcept C2779116991 @default.
- W2095388748 hasConcept C2781184567 @default.
- W2095388748 hasConcept C523546767 @default.
- W2095388748 hasConcept C54355233 @default.
- W2095388748 hasConcept C71924100 @default.
- W2095388748 hasConcept C86803240 @default.
- W2095388748 hasConcept C89423630 @default.
- W2095388748 hasConcept C97355855 @default.
- W2095388748 hasConceptScore W2095388748C121332964 @default.
- W2095388748 hasConceptScore W2095388748C142724271 @default.
- W2095388748 hasConceptScore W2095388748C153400128 @default.
- W2095388748 hasConceptScore W2095388748C160448771 @default.
- W2095388748 hasConceptScore W2095388748C203014093 @default.
- W2095388748 hasConceptScore W2095388748C2775959528 @default.
- W2095388748 hasConceptScore W2095388748C2776626339 @default.
- W2095388748 hasConceptScore W2095388748C2777700362 @default.
- W2095388748 hasConceptScore W2095388748C2779116991 @default.
- W2095388748 hasConceptScore W2095388748C2781184567 @default.
- W2095388748 hasConceptScore W2095388748C523546767 @default.
- W2095388748 hasConceptScore W2095388748C54355233 @default.
- W2095388748 hasConceptScore W2095388748C71924100 @default.
- W2095388748 hasConceptScore W2095388748C86803240 @default.
- W2095388748 hasConceptScore W2095388748C89423630 @default.
- W2095388748 hasConceptScore W2095388748C97355855 @default.
- W2095388748 hasIssue "1" @default.
- W2095388748 hasLocation W20953887481 @default.
- W2095388748 hasLocation W20953887482 @default.
- W2095388748 hasOpenAccess W2095388748 @default.
- W2095388748 hasPrimaryLocation W20953887481 @default.
- W2095388748 hasRelatedWork W1997192444 @default.
- W2095388748 hasRelatedWork W2044909189 @default.
- W2095388748 hasRelatedWork W2058355886 @default.
- W2095388748 hasRelatedWork W2095388748 @default.
- W2095388748 hasRelatedWork W2153789344 @default.
- W2095388748 hasRelatedWork W2187766237 @default.
- W2095388748 hasRelatedWork W2398578226 @default.
- W2095388748 hasRelatedWork W2401060954 @default.
- W2095388748 hasRelatedWork W2439843977 @default.
- W2095388748 hasRelatedWork W812338689 @default.
- W2095388748 hasVolume "50" @default.
- W2095388748 isParatext "false" @default.
- W2095388748 isRetracted "false" @default.
- W2095388748 magId "2095388748" @default.
- W2095388748 workType "article" @default.