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- W2095389529 endingPage "7534" @default.
- W2095389529 startingPage "7517" @default.
- W2095389529 abstract "Coenzyme Q (Q or ubiquinone) is a redox active lipid composed of a fully substituted benzoquinone ring and a polyisoprenoid tail and is required for mitochondrial electron transport. In the yeast Saccharomyces cerevisiae, Q is synthesized by the products of 11 known genes, COQ1–COQ9, YAH1, and ARH1. The function of some of the Coq proteins remains unknown, and several steps in the Q biosynthetic pathway are not fully characterized. Several of the Coq proteins are associated in a macromolecular complex on the matrix face of the inner mitochondrial membrane, and this complex is required for efficient Q synthesis. Here, we further characterize this complex via immunoblotting and proteomic analysis of tandem affinity-purified tagged Coq proteins. We show that Coq8, a putative kinase required for the stability of the Q biosynthetic complex, is associated with a Coq6-containing complex. Additionally Q6 and late stage Q biosynthetic intermediates were also found to co-purify with the complex. A mitochondrial protein of unknown function, encoded by the YLR290C open reading frame, is also identified as a constituent of the complex and is shown to be required for efficient de novo Q biosynthesis. Given its effect on Q synthesis and its association with the biosynthetic complex, we propose that the open reading frame YLR290C be designated COQ11." @default.
- W2095389529 created "2016-06-24" @default.
- W2095389529 creator A5003299197 @default.
- W2095389529 creator A5004905607 @default.
- W2095389529 creator A5021096925 @default.
- W2095389529 creator A5023529029 @default.
- W2095389529 creator A5026118622 @default.
- W2095389529 creator A5052051439 @default.
- W2095389529 creator A5053230113 @default.
- W2095389529 creator A5055648577 @default.
- W2095389529 creator A5088070159 @default.
- W2095389529 date "2015-03-01" @default.
- W2095389529 modified "2023-10-15" @default.
- W2095389529 title "Identification of Coq11, a New Coenzyme Q Biosynthetic Protein in the CoQ-Synthome in Saccharomyces cerevisiae" @default.
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- W2095389529 doi "https://doi.org/10.1074/jbc.m114.633131" @default.