FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095403735> ?p ?o ?g. }

• W2095403735 endingPage "980" @default.
• W2095403735 startingPage "973" @default.
• W2095403735 abstract "AbstractPurpose: The effects of the heat shock protein 90 (Hsp90) inhibitor geldanamycin (GA) were examined on the radiosensitivity and signal transduction pathways in human tumour cell lines.Materials and methods: Two human cell lines, SQ‐5 and DLD‐1, derived from lung carcinoma and colon adenocarcinoma, respectively, were incubated for 16 h at 37°C in medium containing 0.2 µM GA. The cells were then irradiated with X‐rays and incubated with GA for a further 8 h. Radiation sensitivity was determined by clonogenic assays and protein levels were examined by Western blotting.Results: GA radiosensitized both cell lines, but potentiated X‐ray sensitivity more in SQ‐5 than in DLD‐1 cells. It was found that GA depleted EGFR and ErbB‐2 in DLD‐1 cells and depleted only ErbB‐2 in SQ‐5 cells. GA also reduced the expression of Akt and phosphorylated Akt (pAkt) expression in SQ‐5 cells. In addition, the ratio (%) of apoptotic cells and poly [ADP‐ribose] polymerase cleavage increased in SQ‐5 but not in DLD‐1 cells after exposure to GA and X‐ray irradiation. The findings suggest that GA enhances the radiation sensitivity of human tumour cells by inhibiting the EGFR signal transduction system and the Akt signalling pathway.Conclusion: Targeting Hsp90 with GA provides a promising experimental strategy for radiosensitization of carcinoma." @default.
• W2095403735 created "2016-06-24" @default.
• W2095403735 creator A5055634358 @default.
• W2095403735 creator A5081323615 @default.
• W2095403735 creator A5085107380 @default.
• W2095403735 creator A5091783279 @default.
• W2095403735 date "2003-12-01" @default.
• W2095403735 modified "2023-10-18" @default.
• W2095403735 title "Geldanamycin, an inhibitor of Hsp90, sensitizes human tumour cells to radiation" @default.
• W2095403735 cites W1482905183 @default.
• W2095403735 cites W1555549645 @default.
• W2095403735 cites W1586440254 @default.
• W2095403735 cites W1706238475 @default.
• W2095403735 cites W1993216157 @default.
• W2095403735 cites W1998038367 @default.
• W2095403735 cites W2023797932 @default.
• W2095403735 cites W2024306318 @default.
• W2095403735 cites W2047782251 @default.
• W2095403735 cites W2068345721 @default.
• W2095403735 cites W2075338210 @default.
• W2095403735 cites W2080053266 @default.
• W2095403735 cites W2085643470 @default.
• W2095403735 cites W2097767970 @default.
• W2095403735 cites W2137035181 @default.
• W2095403735 cites W2139306838 @default.
• W2095403735 cites W2141393790 @default.
• W2095403735 cites W2161810908 @default.
• W2095403735 doi "https://doi.org/10.1080/09553000310001626135" @default.
• W2095403735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14713575" @default.
• W2095403735 hasPublicationYear "2003" @default.
• W2095403735 type Work @default.
• W2095403735 sameAs 2095403735 @default.
• W2095403735 citedByCount "70" @default.
• W2095403735 countsByYear W20954037352012 @default.
• W2095403735 countsByYear W20954037352013 @default.
• W2095403735 countsByYear W20954037352014 @default.
• W2095403735 countsByYear W20954037352015 @default.
• W2095403735 countsByYear W20954037352016 @default.
• W2095403735 countsByYear W20954037352017 @default.
• W2095403735 countsByYear W20954037352018 @default.
• W2095403735 countsByYear W20954037352019 @default.
• W2095403735 countsByYear W20954037352020 @default.
• W2095403735 countsByYear W20954037352022 @default.
• W2095403735 crossrefType "journal-article" @default.
• W2095403735 hasAuthorship W2095403735A5055634358 @default.
• W2095403735 hasAuthorship W2095403735A5081323615 @default.
• W2095403735 hasAuthorship W2095403735A5085107380 @default.
• W2095403735 hasAuthorship W2095403735A5091783279 @default.
• W2095403735 hasConcept C104317684 @default.
• W2095403735 hasConcept C111337013 @default.
• W2095403735 hasConcept C117262875 @default.
• W2095403735 hasConcept C121332964 @default.
• W2095403735 hasConcept C126322002 @default.
• W2095403735 hasConcept C153911025 @default.
• W2095403735 hasConcept C185544564 @default.
• W2095403735 hasConcept C185592680 @default.
• W2095403735 hasConcept C190283241 @default.
• W2095403735 hasConcept C205260736 @default.
• W2095403735 hasConcept C206684579 @default.
• W2095403735 hasConcept C26114605 @default.
• W2095403735 hasConcept C2775932338 @default.
• W2095403735 hasConcept C2777560012 @default.
• W2095403735 hasConcept C2780297055 @default.
• W2095403735 hasConcept C502942594 @default.
• W2095403735 hasConcept C509974204 @default.
• W2095403735 hasConcept C54355233 @default.
• W2095403735 hasConcept C55493867 @default.
• W2095403735 hasConcept C62478195 @default.
• W2095403735 hasConcept C71924100 @default.
• W2095403735 hasConcept C75217442 @default.
• W2095403735 hasConcept C81885089 @default.
• W2095403735 hasConcept C86554907 @default.
• W2095403735 hasConcept C86803240 @default.
• W2095403735 hasConcept C95444343 @default.
• W2095403735 hasConceptScore W2095403735C104317684 @default.
• W2095403735 hasConceptScore W2095403735C111337013 @default.
• W2095403735 hasConceptScore W2095403735C117262875 @default.
• W2095403735 hasConceptScore W2095403735C121332964 @default.
• W2095403735 hasConceptScore W2095403735C126322002 @default.
• W2095403735 hasConceptScore W2095403735C153911025 @default.
• W2095403735 hasConceptScore W2095403735C185544564 @default.
• W2095403735 hasConceptScore W2095403735C185592680 @default.
• W2095403735 hasConceptScore W2095403735C190283241 @default.
• W2095403735 hasConceptScore W2095403735C205260736 @default.
• W2095403735 hasConceptScore W2095403735C206684579 @default.
• W2095403735 hasConceptScore W2095403735C26114605 @default.
• W2095403735 hasConceptScore W2095403735C2775932338 @default.
• W2095403735 hasConceptScore W2095403735C2777560012 @default.
• W2095403735 hasConceptScore W2095403735C2780297055 @default.
• W2095403735 hasConceptScore W2095403735C502942594 @default.
• W2095403735 hasConceptScore W2095403735C509974204 @default.
• W2095403735 hasConceptScore W2095403735C54355233 @default.
• W2095403735 hasConceptScore W2095403735C55493867 @default.
• W2095403735 hasConceptScore W2095403735C62478195 @default.
• W2095403735 hasConceptScore W2095403735C71924100 @default.
• W2095403735 hasConceptScore W2095403735C75217442 @default.
• W2095403735 hasConceptScore W2095403735C81885089 @default.
• W2095403735 hasConceptScore W2095403735C86554907 @default.

• next