Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095406210> ?p ?o ?g. }
- W2095406210 endingPage "63" @default.
- W2095406210 startingPage "59" @default.
- W2095406210 abstract "Apigenin, a plant‐derived flavone, is a potent inhibitor of cell proliferation and angiogenesis, but the mechanisms leading to the pathological anti‐angiogenic effects of apigenin are still unclear. In this study, we found that apigenin inhibited the hypoxia‐induced expression of vascular endothelial growth factor (VEGF) mRNA in human umbilical artery endothelial cells. Apigenin also suppressed the expression of erythropoietin mRNA, which is a typical hypoxia‐inducible gene, via the degradation of hypoxia‐inducible factor 1 (HIF‐1) α. We investigated the effect of apigenin on the interaction of HIF‐1α with heat shock protein 90 (Hsp90), which is reported to be important for the stabilization of HIF‐1α, and found that VEGF expression was inhibited via degradation of HIF‐1α through interference with the function of Hsp90." @default.
- W2095406210 created "2016-06-24" @default.
- W2095406210 creator A5014115966 @default.
- W2095406210 creator A5036137017 @default.
- W2095406210 creator A5045181951 @default.
- W2095406210 date "2004-08-28" @default.
- W2095406210 modified "2023-10-14" @default.
- W2095406210 title "Apigenin suppresses the expression of VEGF, an important factor for angiogenesis, in endothelial cells via degradation of HIF‐1α protein" @default.
- W2095406210 cites W1965849506 @default.
- W2095406210 cites W1966621021 @default.
- W2095406210 cites W1973092951 @default.
- W2095406210 cites W1973892250 @default.
- W2095406210 cites W1983937756 @default.
- W2095406210 cites W1987594745 @default.
- W2095406210 cites W1992924591 @default.
- W2095406210 cites W2014996117 @default.
- W2095406210 cites W2021780953 @default.
- W2095406210 cites W2024206845 @default.
- W2095406210 cites W2026151657 @default.
- W2095406210 cites W2040031153 @default.
- W2095406210 cites W2042436634 @default.
- W2095406210 cites W2075054245 @default.
- W2095406210 cites W2080812076 @default.
- W2095406210 cites W2085609942 @default.
- W2095406210 cites W2098972920 @default.
- W2095406210 cites W2108222684 @default.
- W2095406210 cites W2120090919 @default.
- W2095406210 cites W2133193034 @default.
- W2095406210 cites W2143965341 @default.
- W2095406210 cites W2144625075 @default.
- W2095406210 cites W2146097802 @default.
- W2095406210 cites W2163069245 @default.
- W2095406210 cites W2180159320 @default.
- W2095406210 cites W4210644838 @default.
- W2095406210 doi "https://doi.org/10.1016/j.febslet.2004.08.036" @default.
- W2095406210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15388333" @default.
- W2095406210 hasPublicationYear "2004" @default.
- W2095406210 type Work @default.
- W2095406210 sameAs 2095406210 @default.
- W2095406210 citedByCount "111" @default.
- W2095406210 countsByYear W20954062102012 @default.
- W2095406210 countsByYear W20954062102013 @default.
- W2095406210 countsByYear W20954062102014 @default.
- W2095406210 countsByYear W20954062102015 @default.
- W2095406210 countsByYear W20954062102016 @default.
- W2095406210 countsByYear W20954062102017 @default.
- W2095406210 countsByYear W20954062102018 @default.
- W2095406210 countsByYear W20954062102019 @default.
- W2095406210 countsByYear W20954062102020 @default.
- W2095406210 countsByYear W20954062102021 @default.
- W2095406210 countsByYear W20954062102022 @default.
- W2095406210 countsByYear W20954062102023 @default.
- W2095406210 crossrefType "journal-article" @default.
- W2095406210 hasAuthorship W2095406210A5014115966 @default.
- W2095406210 hasAuthorship W2095406210A5036137017 @default.
- W2095406210 hasAuthorship W2095406210A5045181951 @default.
- W2095406210 hasBestOaLocation W20954062101 @default.
- W2095406210 hasConcept C104317684 @default.
- W2095406210 hasConcept C146285616 @default.
- W2095406210 hasConcept C160450060 @default.
- W2095406210 hasConcept C167734588 @default.
- W2095406210 hasConcept C178790620 @default.
- W2095406210 hasConcept C185592680 @default.
- W2095406210 hasConcept C205260736 @default.
- W2095406210 hasConcept C2775932338 @default.
- W2095406210 hasConcept C2777025900 @default.
- W2095406210 hasConcept C2778004101 @default.
- W2095406210 hasConcept C2778609962 @default.
- W2095406210 hasConcept C2779054382 @default.
- W2095406210 hasConcept C2780394083 @default.
- W2095406210 hasConcept C31194975 @default.
- W2095406210 hasConcept C502942594 @default.
- W2095406210 hasConcept C540031477 @default.
- W2095406210 hasConcept C55493867 @default.
- W2095406210 hasConcept C7836513 @default.
- W2095406210 hasConcept C86803240 @default.
- W2095406210 hasConcept C95444343 @default.
- W2095406210 hasConceptScore W2095406210C104317684 @default.
- W2095406210 hasConceptScore W2095406210C146285616 @default.
- W2095406210 hasConceptScore W2095406210C160450060 @default.
- W2095406210 hasConceptScore W2095406210C167734588 @default.
- W2095406210 hasConceptScore W2095406210C178790620 @default.
- W2095406210 hasConceptScore W2095406210C185592680 @default.
- W2095406210 hasConceptScore W2095406210C205260736 @default.
- W2095406210 hasConceptScore W2095406210C2775932338 @default.
- W2095406210 hasConceptScore W2095406210C2777025900 @default.
- W2095406210 hasConceptScore W2095406210C2778004101 @default.
- W2095406210 hasConceptScore W2095406210C2778609962 @default.
- W2095406210 hasConceptScore W2095406210C2779054382 @default.
- W2095406210 hasConceptScore W2095406210C2780394083 @default.
- W2095406210 hasConceptScore W2095406210C31194975 @default.
- W2095406210 hasConceptScore W2095406210C502942594 @default.
- W2095406210 hasConceptScore W2095406210C540031477 @default.
- W2095406210 hasConceptScore W2095406210C55493867 @default.
- W2095406210 hasConceptScore W2095406210C7836513 @default.
- W2095406210 hasConceptScore W2095406210C86803240 @default.
- W2095406210 hasConceptScore W2095406210C95444343 @default.
- W2095406210 hasIssue "1-3" @default.