FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095417811> ?p ?o ?g. }

• W2095417811 endingPage "e23714" @default.
• W2095417811 startingPage "e23714" @default.
• W2095417811 abstract "Asthma is a chronic inflammatory disease with a strong genetic predisposition. A major challenge for candidate gene association studies in asthma is the selection of biologically relevant genes.Using epithelial RNA expression arrays, HapMap allele frequency variation, and the literature, we identified six possible candidate susceptibility genes for childhood asthma including ADCY2, DNAH5, KIF3A, PDE4B, PLAU, SPRR2B. To evaluate these genes, we compared the genotypes of 194 predominantly tagging SNPs in 790 asthmatic, allergic and non-allergic children. We found that SNPs in all six genes were nominally associated with asthma (p<0.05) in our discovery cohort and in three independent cohorts at either the SNP or gene level (p<0.05). Further, we determined that our selection approach was superior to random selection of genes either differentially expressed in asthmatics compared to controls (p = 0.0049) or selected based on the literature alone (p = 0.0049), substantiating the validity of our gene selection approach. Importantly, we observed that 7 of 9 SNPs in the KIF3A gene more than doubled the odds of asthma (OR = 2.3, p<0.0001) and increased the odds of allergic disease (OR = 1.8, p<0.008). Our data indicate that KIF3A rs7737031 (T-allele) has an asthma population attributable risk of 18.5%. The association between KIF3A rs7737031 and asthma was validated in 3 independent populations, further substantiating the validity of our gene selection approach.Our study demonstrates that KIF3A, a member of the kinesin superfamily of microtubule associated motors that are important in the transport of protein complexes within cilia, is a novel candidate gene for childhood asthma. Polymorphisms in KIF3A may in part be responsible for poor mucus and/or allergen clearance from the airways. Furthermore, our study provides a promising framework for the identification and evaluation of novel candidate susceptibility genes." @default.
• W2095417811 created "2016-06-24" @default.
• W2095417811 creator A5001856849 @default.
• W2095417811 creator A5003816961 @default.
• W2095417811 creator A5004750663 @default.
• W2095417811 creator A5005988117 @default.
• W2095417811 creator A5017217536 @default.
• W2095417811 creator A5017737620 @default.
• W2095417811 creator A5018950903 @default.
• W2095417811 creator A5021558797 @default.
• W2095417811 creator A5022033140 @default.
• W2095417811 creator A5023724713 @default.
• W2095417811 creator A5028597289 @default.
• W2095417811 creator A5037499657 @default.
• W2095417811 creator A5038372761 @default.
• W2095417811 creator A5039953200 @default.
• W2095417811 creator A5041063062 @default.
• W2095417811 creator A5043735279 @default.
• W2095417811 creator A5043839950 @default.
• W2095417811 creator A5059093059 @default.
• W2095417811 creator A5067060534 @default.
• W2095417811 creator A5068304714 @default.
• W2095417811 creator A5073945841 @default.
• W2095417811 creator A5080037243 @default.
• W2095417811 creator A5080971226 @default.
• W2095417811 creator A5082245105 @default.
• W2095417811 creator A5083265318 @default.
• W2095417811 creator A5083476110 @default.
• W2095417811 creator A5088861717 @default.
• W2095417811 creator A5090022167 @default.
• W2095417811 date "2011-08-30" @default.
• W2095417811 modified "2023-10-15" @default.
• W2095417811 title "Identification of KIF3A as a Novel Candidate Gene for Childhood Asthma Using RNA Expression and Population Allelic Frequencies Differences" @default.
• W2095417811 cites W1587881343 @default.
• W2095417811 cites W1600162161 @default.
• W2095417811 cites W1980991473 @default.
• W2095417811 cites W1982663312 @default.
• W2095417811 cites W1992436001 @default.
• W2095417811 cites W2000864160 @default.
• W2095417811 cites W2003298782 @default.
• W2095417811 cites W2007539174 @default.
• W2095417811 cites W2009104876 @default.
• W2095417811 cites W2015234886 @default.
• W2095417811 cites W2015408724 @default.
• W2095417811 cites W2023122863 @default.
• W2095417811 cites W2036198235 @default.
• W2095417811 cites W2049793994 @default.
• W2095417811 cites W2051008458 @default.
• W2095417811 cites W2053787162 @default.
• W2095417811 cites W2054855935 @default.
• W2095417811 cites W2058792575 @default.
• W2095417811 cites W2066602623 @default.
• W2095417811 cites W2070868995 @default.
• W2095417811 cites W2073174918 @default.
• W2095417811 cites W2075923653 @default.
• W2095417811 cites W2094645048 @default.
• W2095417811 cites W2097574142 @default.
• W2095417811 cites W2098286297 @default.
• W2095417811 cites W2099570245 @default.
• W2095417811 cites W2113624460 @default.
• W2095417811 cites W2116728425 @default.
• W2095417811 cites W2116782829 @default.
• W2095417811 cites W2119279196 @default.
• W2095417811 cites W2134888545 @default.
• W2095417811 cites W2140040043 @default.
• W2095417811 cites W2143668703 @default.
• W2095417811 cites W2147280137 @default.
• W2095417811 cites W2148209880 @default.
• W2095417811 cites W2149796867 @default.
• W2095417811 cites W2154261437 @default.
• W2095417811 cites W2157752701 @default.
• W2095417811 cites W2161633633 @default.
• W2095417811 cites W2164061579 @default.
• W2095417811 cites W2169218570 @default.
• W2095417811 cites W2169932837 @default.
• W2095417811 cites W2305115360 @default.
• W2095417811 cites W4229967758 @default.
• W2095417811 cites W4231311503 @default.
• W2095417811 doi "https://doi.org/10.1371/journal.pone.0023714" @default.
• W2095417811 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3166061" @default.
• W2095417811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21912604" @default.
• W2095417811 hasPublicationYear "2011" @default.
• W2095417811 type Work @default.
• W2095417811 sameAs 2095417811 @default.
• W2095417811 citedByCount "43" @default.
• W2095417811 countsByYear W20954178112012 @default.
• W2095417811 countsByYear W20954178112014 @default.
• W2095417811 countsByYear W20954178112015 @default.
• W2095417811 countsByYear W20954178112016 @default.
• W2095417811 countsByYear W20954178112017 @default.
• W2095417811 countsByYear W20954178112018 @default.
• W2095417811 countsByYear W20954178112019 @default.
• W2095417811 countsByYear W20954178112020 @default.
• W2095417811 countsByYear W20954178112021 @default.
• W2095417811 countsByYear W20954178112022 @default.
• W2095417811 countsByYear W20954178112023 @default.
• W2095417811 crossrefType "journal-article" @default.
• W2095417811 hasAuthorship W2095417811A5001856849 @default.

• next