FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095429914> ?p ?o ?g. }

• W2095429914 endingPage "938" @default.
• W2095429914 startingPage "932" @default.
• W2095429914 abstract "We examined the functional role of the phosphatidylinositol 3′-kinase pathway in the growth and survival of cell lines of T-cell origin. Pharmacological inhibition of PI3′-kinase using LY294002 resulted in apoptosis of acute lymphoblastic T-cell leukemia (T-ALL) cell lines including CEM, Jurkat, and MOLT-4. On the other hand, the cutaneous T-cell lymphoma cell line HUT-78 was found to be refractory to LY294002- inducible apoptosis. Sensitivity or resistance to pharmacological inhibitors of PI3′-kinase correlated with tumor suppressor PTEN gene expression, as sensitive T-ALL cells do not express PTEN and have high level of activated AKT, in contrast to HUT-78 cells. Our data demonstrate that inhibition of PI3′-kinase results in dephosphorylation of AKT and partial inhibition of Bcl-xL expression in T-ALL cells, but not in HUT-78 cells. Interestingly, HUT-78 cells were also found to express higher levels of Bcl-xL protein as compared to T-ALL cells. Inhibition of PI3′-kinase also induces release of cytochrome c from mitochondria and activation of caspase-3 and PARP in all T-ALL cell lines tested, but not in HUT-78 cells. Taken altogether, our data demonstrate that the PI3′-kinase/AKT pathway plays a major role in the growth and survival of PTEN-null T-ALL cells, and identify this cascade as promising target for therapeutic intervention in acute T-cell leukemias." @default.
• W2095429914 created "2016-06-24" @default.
• W2095429914 creator A5012192417 @default.
• W2095429914 creator A5036676949 @default.
• W2095429914 creator A5039411132 @default.
• W2095429914 creator A5051335860 @default.
• W2095429914 creator A5055366985 @default.
• W2095429914 date "2004-07-01" @default.
• W2095429914 modified "2023-10-07" @default.
• W2095429914 title "Inhibition of phosphatidylinositol 3′-kinase induces preferentially killing of PTEN-null T leukemias through AKT pathway" @default.
• W2095429914 cites W1482905183 @default.
• W2095429914 cites W1489145507 @default.
• W2095429914 cites W1529396499 @default.
• W2095429914 cites W1568605582 @default.
• W2095429914 cites W1652264402 @default.
• W2095429914 cites W1971819575 @default.
• W2095429914 cites W1973577899 @default.
• W2095429914 cites W1984418041 @default.
• W2095429914 cites W1993216157 @default.
• W2095429914 cites W1998214332 @default.
• W2095429914 cites W2001838080 @default.
• W2095429914 cites W2007530728 @default.
• W2095429914 cites W2011485783 @default.
• W2095429914 cites W2017191360 @default.
• W2095429914 cites W2019189562 @default.
• W2095429914 cites W2024306318 @default.
• W2095429914 cites W2033801757 @default.
• W2095429914 cites W2043806397 @default.
• W2095429914 cites W2047598460 @default.
• W2095429914 cites W2049187899 @default.
• W2095429914 cites W2058138221 @default.
• W2095429914 cites W2068427129 @default.
• W2095429914 cites W2081427260 @default.
• W2095429914 cites W2083374779 @default.
• W2095429914 cites W2097767970 @default.
• W2095429914 cites W2111752734 @default.
• W2095429914 cites W2127566892 @default.
• W2095429914 cites W2137035181 @default.
• W2095429914 cites W2388163742 @default.
• W2095429914 doi "https://doi.org/10.1016/j.bbrc.2004.06.038" @default.
• W2095429914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15240138" @default.
• W2095429914 hasPublicationYear "2004" @default.
• W2095429914 type Work @default.
• W2095429914 sameAs 2095429914 @default.
• W2095429914 citedByCount "69" @default.
• W2095429914 countsByYear W20954299142012 @default.
• W2095429914 countsByYear W20954299142013 @default.
• W2095429914 countsByYear W20954299142014 @default.
• W2095429914 countsByYear W20954299142015 @default.
• W2095429914 countsByYear W20954299142017 @default.
• W2095429914 countsByYear W20954299142018 @default.
• W2095429914 countsByYear W20954299142020 @default.
• W2095429914 countsByYear W20954299142023 @default.
• W2095429914 crossrefType "journal-article" @default.
• W2095429914 hasAuthorship W2095429914A5012192417 @default.
• W2095429914 hasAuthorship W2095429914A5036676949 @default.
• W2095429914 hasAuthorship W2095429914A5039411132 @default.
• W2095429914 hasAuthorship W2095429914A5051335860 @default.
• W2095429914 hasAuthorship W2095429914A5055366985 @default.
• W2095429914 hasConcept C153911025 @default.
• W2095429914 hasConcept C179464577 @default.
• W2095429914 hasConcept C184235292 @default.
• W2095429914 hasConcept C190283241 @default.
• W2095429914 hasConcept C203014093 @default.
• W2095429914 hasConcept C2776090121 @default.
• W2095429914 hasConcept C2776912716 @default.
• W2095429914 hasConcept C2777609662 @default.
• W2095429914 hasConcept C2780610907 @default.
• W2095429914 hasConcept C502942594 @default.
• W2095429914 hasConcept C54355233 @default.
• W2095429914 hasConcept C55493867 @default.
• W2095429914 hasConcept C62112901 @default.
• W2095429914 hasConcept C62478195 @default.
• W2095429914 hasConcept C75217442 @default.
• W2095429914 hasConcept C81885089 @default.
• W2095429914 hasConcept C86554907 @default.
• W2095429914 hasConcept C86803240 @default.
• W2095429914 hasConcept C8891405 @default.
• W2095429914 hasConcept C95444343 @default.
• W2095429914 hasConceptScore W2095429914C153911025 @default.
• W2095429914 hasConceptScore W2095429914C179464577 @default.
• W2095429914 hasConceptScore W2095429914C184235292 @default.
• W2095429914 hasConceptScore W2095429914C190283241 @default.
• W2095429914 hasConceptScore W2095429914C203014093 @default.
• W2095429914 hasConceptScore W2095429914C2776090121 @default.
• W2095429914 hasConceptScore W2095429914C2776912716 @default.
• W2095429914 hasConceptScore W2095429914C2777609662 @default.
• W2095429914 hasConceptScore W2095429914C2780610907 @default.
• W2095429914 hasConceptScore W2095429914C502942594 @default.
• W2095429914 hasConceptScore W2095429914C54355233 @default.
• W2095429914 hasConceptScore W2095429914C55493867 @default.
• W2095429914 hasConceptScore W2095429914C62112901 @default.
• W2095429914 hasConceptScore W2095429914C62478195 @default.
• W2095429914 hasConceptScore W2095429914C75217442 @default.
• W2095429914 hasConceptScore W2095429914C81885089 @default.
• W2095429914 hasConceptScore W2095429914C86554907 @default.
• W2095429914 hasConceptScore W2095429914C86803240 @default.
• W2095429914 hasConceptScore W2095429914C8891405 @default.

• next