FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095432971> ?p ?o ?g. }

• W2095432971 endingPage "676" @default.
• W2095432971 startingPage "671" @default.
• W2095432971 abstract "Trop-2/EGP-1/GA733-1 is a recently identified cell surface glycoprotein highly expressed by human carcinomas. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Thus, we investigated whether Trop-2 might be a functional signaling molecule. Using the fluorescent probe Fura-2, we assayed the cytoplasmic calcium levels in human cancer cells stimulated with anti-Trop-2 or control antibodies. Three anti-Trop-2 MAbs, Rs7-7G11, MOv16 and 162-46.2 specifically induced a transient intracellular calcium level increment in up to 40% of the experiments performed. Polyclonal antisera recognizing recombinant Trop-2 molecules possessed a much lower stimulation efficiency. The average latency of antibody-induced Ca2+ rise for OvCa-432 cells was 64+/-26 sec. Internal Ca2+ concentrations reached peaks of 190+/-24 nM vs. basal levels of 61+/-4 nM and returned to baseline within 193+/-37 sec. Similar values were obtained in MCF-7 cells. For comparison, stimulation of P2-purinergic receptors on MCF-7 and OvCa-432 cells induced a Ca2+ rise in most cases, leading to average internal Ca2+ concentrations of 297+/-41 and 391+/-39 nM, respectively. Our findings show that Trop-2 transduces an intracellular calcium signal, are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand." @default.
• W2095432971 created "2016-06-24" @default.
• W2095432971 creator A5026764999 @default.
• W2095432971 creator A5047098934 @default.
• W2095432971 creator A5052116403 @default.
• W2095432971 creator A5065863026 @default.
• W2095432971 date "1998-05-29" @default.
• W2095432971 modified "2023-10-15" @default.
• W2095432971 title "Human TROP-2 is a tumor-associated calcium signal transducer" @default.
• W2095432971 cites W1522410151 @default.
• W2095432971 cites W1555375665 @default.
• W2095432971 cites W1575682645 @default.
• W2095432971 cites W1873199501 @default.
• W2095432971 cites W1921797592 @default.
• W2095432971 cites W1966709711 @default.
• W2095432971 cites W1968612252 @default.
• W2095432971 cites W1973179309 @default.
• W2095432971 cites W1975444882 @default.
• W2095432971 cites W1981943594 @default.
• W2095432971 cites W1989866518 @default.
• W2095432971 cites W1993056856 @default.
• W2095432971 cites W2002426426 @default.
• W2095432971 cites W2012012820 @default.
• W2095432971 cites W2040719899 @default.
• W2095432971 cites W2044087150 @default.
• W2095432971 cites W2114401576 @default.
• W2095432971 cites W2114420549 @default.
• W2095432971 cites W2116136455 @default.
• W2095432971 cites W2128100381 @default.
• W2095432971 cites W2132864109 @default.
• W2095432971 cites W2138600707 @default.
• W2095432971 cites W2144966307 @default.
• W2095432971 cites W2154083290 @default.
• W2095432971 cites W2174190166 @default.
• W2095432971 doi "https://doi.org/10.1002/(sici)1097-0215(19980529)76:5<671::aid-ijc10>3.0.co;2-7" @default.
• W2095432971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9610724" @default.
• W2095432971 hasPublicationYear "1998" @default.
• W2095432971 type Work @default.
• W2095432971 sameAs 2095432971 @default.
• W2095432971 citedByCount "179" @default.
• W2095432971 countsByYear W20954329712012 @default.
• W2095432971 countsByYear W20954329712013 @default.
• W2095432971 countsByYear W20954329712014 @default.
• W2095432971 countsByYear W20954329712015 @default.
• W2095432971 countsByYear W20954329712016 @default.
• W2095432971 countsByYear W20954329712017 @default.
• W2095432971 countsByYear W20954329712018 @default.
• W2095432971 countsByYear W20954329712019 @default.
• W2095432971 countsByYear W20954329712020 @default.
• W2095432971 countsByYear W20954329712021 @default.
• W2095432971 countsByYear W20954329712022 @default.
• W2095432971 countsByYear W20954329712023 @default.
• W2095432971 crossrefType "journal-article" @default.
• W2095432971 hasAuthorship W2095432971A5026764999 @default.
• W2095432971 hasAuthorship W2095432971A5047098934 @default.
• W2095432971 hasAuthorship W2095432971A5052116403 @default.
• W2095432971 hasAuthorship W2095432971A5065863026 @default.
• W2095432971 hasConcept C126322002 @default.
• W2095432971 hasConcept C134018914 @default.
• W2095432971 hasConcept C153911025 @default.
• W2095432971 hasConcept C159654299 @default.
• W2095432971 hasConcept C170493617 @default.
• W2095432971 hasConcept C181080969 @default.
• W2095432971 hasConcept C181199279 @default.
• W2095432971 hasConcept C190062978 @default.
• W2095432971 hasConcept C201571599 @default.
• W2095432971 hasConcept C203014093 @default.
• W2095432971 hasConcept C24998067 @default.
• W2095432971 hasConcept C2776165026 @default.
• W2095432971 hasConcept C2777427919 @default.
• W2095432971 hasConcept C2777553839 @default.
• W2095432971 hasConcept C2778470358 @default.
• W2095432971 hasConcept C2781387506 @default.
• W2095432971 hasConcept C519063684 @default.
• W2095432971 hasConcept C55493867 @default.
• W2095432971 hasConcept C71924100 @default.
• W2095432971 hasConcept C79879829 @default.
• W2095432971 hasConcept C86803240 @default.
• W2095432971 hasConcept C95444343 @default.
• W2095432971 hasConcept C956191 @default.
• W2095432971 hasConcept C98539663 @default.
• W2095432971 hasConceptScore W2095432971C126322002 @default.
• W2095432971 hasConceptScore W2095432971C134018914 @default.
• W2095432971 hasConceptScore W2095432971C153911025 @default.
• W2095432971 hasConceptScore W2095432971C159654299 @default.
• W2095432971 hasConceptScore W2095432971C170493617 @default.
• W2095432971 hasConceptScore W2095432971C181080969 @default.
• W2095432971 hasConceptScore W2095432971C181199279 @default.
• W2095432971 hasConceptScore W2095432971C190062978 @default.
• W2095432971 hasConceptScore W2095432971C201571599 @default.
• W2095432971 hasConceptScore W2095432971C203014093 @default.
• W2095432971 hasConceptScore W2095432971C24998067 @default.
• W2095432971 hasConceptScore W2095432971C2776165026 @default.
• W2095432971 hasConceptScore W2095432971C2777427919 @default.
• W2095432971 hasConceptScore W2095432971C2777553839 @default.
• W2095432971 hasConceptScore W2095432971C2778470358 @default.
• W2095432971 hasConceptScore W2095432971C2781387506 @default.
• W2095432971 hasConceptScore W2095432971C519063684 @default.

• next