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- W2095433065 abstract "A transgenic (Tg) mouse expressing human IL-15 was generated to define the role of IL-15 in the normal immune response. Overexpression of IL-15 resulted in an increase of NK, CD44 hi CD8 memory T cells, and γδ T cells. Additionally, we observed the emergence of a novel type of NK-T cells with CD8αα′ expression. Due to the expansion and activation of NK cells, the IL-15Tg mouse showed enhanced innate immunity. In adaptive T cell immunity, the roles of IL-15 contrasted with those of IL-2. IL-15 inhibited IL-2-induced T cell death, which plays a role in the maintenance of peripheral self-tolerance. IL-15 thus seems to contribute to enhanced immune memory by selectively propagating memory T cells and by blocking T cell death mediated by IL-2." @default.
- W2095433065 created "2016-06-24" @default.
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- W2095433065 date "2000-10-03" @default.
- W2095433065 modified "2023-09-30" @default.
- W2095433065 title "IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice" @default.
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- W2095433065 doi "https://doi.org/10.1073/pnas.200363097" @default.
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