FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095450147> ?p ?o ?g. }

• W2095450147 endingPage "120" @default.
• W2095450147 startingPage "97" @default.
• W2095450147 abstract "(1) Co-operation between a laboratory interested in developing the theory for protein secondary structure prediction methods and a laboratory interested in applying and comparing such methods has led to the development of a simple predictive algorithm. (2) Four-state predictions, in which each residue is unambiguously assigned one conformational state of α-helix, extended chain, reverse turn or coil, predict 49% of residue states correctly (in a sample of 26 proteins) when the overall helix and extended-chain content is not taken into account. (3) When the relative abundances of helix, extended chain, reverse turn and coil observed by X-ray crystallography are taken into account, a single constant for each protein and type of conformation can be used to bias the prediction. When predictions are optimized in this way, 63% of all residue states are unambiguously and correctly assigned. (4) By analysing the nature of the bias required, proteins can be classified into helix-rich types, pleated-sheet-rich types, and so on. It is shown that, if the type of protein can be determined even approximately by circular dichroism, 57% of residue states can be correctly predicted without taking into account the X-ray structure. Further, comparable predictions can be obtained if, instead of circular dichroism, preliminary predictions are made to assess the protein type. (5) It is emphasized that the numbers quoted here depend on the method used to assess accuracy, and the algorithm is shown to be at least as good as, and usually superior to, the reported prediction methods assessed in the same way. (6) Ways of further enhancing predictions by the use of additional information from hydrophobic triplets and homologous sequences are also explored. Hydro-phobic triplet information does not significantly improve predictive power and it is concluded that this information is used by proteins in the next stage of folding. On the other hand, the use of homologous sequences appears to be very promising. (7) The implication of these results in protein folding is discussed." @default.
• W2095450147 created "2016-06-24" @default.
• W2095450147 creator A5009453283 @default.
• W2095450147 creator A5010074895 @default.
• W2095450147 creator A5017976401 @default.
• W2095450147 date "1978-03-01" @default.
• W2095450147 modified "2023-10-14" @default.
• W2095450147 title "Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins" @default.
• W2095450147 cites W1588000118 @default.
• W2095450147 cites W179258906 @default.
• W2095450147 cites W1984099313 @default.
• W2095450147 cites W2010008663 @default.
• W2095450147 cites W2022761661 @default.
• W2095450147 cites W2029851506 @default.
• W2095450147 cites W2031671972 @default.
• W2095450147 cites W2049695588 @default.
• W2095450147 cites W2056958748 @default.
• W2095450147 cites W2061500593 @default.
• W2095450147 cites W2109553965 @default.
• W2095450147 cites W2110967194 @default.
• W2095450147 cites W2201553308 @default.
• W2095450147 cites W2269348795 @default.
• W2095450147 cites W2342123009 @default.
• W2095450147 cites W2394864771 @default.
• W2095450147 cites W2622573615 @default.
• W2095450147 doi "https://doi.org/10.1016/0022-2836(78)90297-8" @default.
• W2095450147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/642007" @default.
• W2095450147 hasPublicationYear "1978" @default.
• W2095450147 type Work @default.
• W2095450147 sameAs 2095450147 @default.
• W2095450147 citedByCount "4418" @default.
• W2095450147 countsByYear W20954501472012 @default.
• W2095450147 countsByYear W20954501472013 @default.
• W2095450147 countsByYear W20954501472014 @default.
• W2095450147 countsByYear W20954501472015 @default.
• W2095450147 countsByYear W20954501472016 @default.
• W2095450147 countsByYear W20954501472017 @default.
• W2095450147 countsByYear W20954501472018 @default.
• W2095450147 countsByYear W20954501472019 @default.
• W2095450147 countsByYear W20954501472020 @default.
• W2095450147 countsByYear W20954501472021 @default.
• W2095450147 countsByYear W20954501472022 @default.
• W2095450147 countsByYear W20954501472023 @default.
• W2095450147 crossrefType "journal-article" @default.
• W2095450147 hasAuthorship W2095450147A5009453283 @default.
• W2095450147 hasAuthorship W2095450147A5010074895 @default.
• W2095450147 hasAuthorship W2095450147A5017976401 @default.
• W2095450147 hasConcept C105168689 @default.
• W2095450147 hasConcept C11413529 @default.
• W2095450147 hasConcept C133571119 @default.
• W2095450147 hasConcept C18051474 @default.
• W2095450147 hasConcept C184538305 @default.
• W2095450147 hasConcept C185592680 @default.
• W2095450147 hasConcept C186060115 @default.
• W2095450147 hasConcept C18903297 @default.
• W2095450147 hasConcept C2778530040 @default.
• W2095450147 hasConcept C2779965526 @default.
• W2095450147 hasConcept C2781338088 @default.
• W2095450147 hasConcept C2993989360 @default.
• W2095450147 hasConcept C33923547 @default.
• W2095450147 hasConcept C47701112 @default.
• W2095450147 hasConcept C515207424 @default.
• W2095450147 hasConcept C55493867 @default.
• W2095450147 hasConcept C62614982 @default.
• W2095450147 hasConcept C8010536 @default.
• W2095450147 hasConcept C86803240 @default.
• W2095450147 hasConceptScore W2095450147C105168689 @default.
• W2095450147 hasConceptScore W2095450147C11413529 @default.
• W2095450147 hasConceptScore W2095450147C133571119 @default.
• W2095450147 hasConceptScore W2095450147C18051474 @default.
• W2095450147 hasConceptScore W2095450147C184538305 @default.
• W2095450147 hasConceptScore W2095450147C185592680 @default.
• W2095450147 hasConceptScore W2095450147C186060115 @default.
• W2095450147 hasConceptScore W2095450147C18903297 @default.
• W2095450147 hasConceptScore W2095450147C2778530040 @default.
• W2095450147 hasConceptScore W2095450147C2779965526 @default.
• W2095450147 hasConceptScore W2095450147C2781338088 @default.
• W2095450147 hasConceptScore W2095450147C2993989360 @default.
• W2095450147 hasConceptScore W2095450147C33923547 @default.
• W2095450147 hasConceptScore W2095450147C47701112 @default.
• W2095450147 hasConceptScore W2095450147C515207424 @default.
• W2095450147 hasConceptScore W2095450147C55493867 @default.
• W2095450147 hasConceptScore W2095450147C62614982 @default.
• W2095450147 hasConceptScore W2095450147C8010536 @default.
• W2095450147 hasConceptScore W2095450147C86803240 @default.
• W2095450147 hasIssue "1" @default.
• W2095450147 hasLocation W20954501471 @default.
• W2095450147 hasLocation W20954501472 @default.
• W2095450147 hasOpenAccess W2095450147 @default.
• W2095450147 hasPrimaryLocation W20954501471 @default.
• W2095450147 hasRelatedWork W2083563479 @default.
• W2095450147 hasRelatedWork W2095450147 @default.
• W2095450147 hasRelatedWork W2110961280 @default.
• W2095450147 hasRelatedWork W2126871981 @default.
• W2095450147 hasRelatedWork W2137712029 @default.
• W2095450147 hasRelatedWork W2407384706 @default.
• W2095450147 hasRelatedWork W2417914725 @default.
• W2095450147 hasRelatedWork W2573983130 @default.

• next