FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095453603> ?p ?o ?g. }

• W2095453603 endingPage "249" @default.
• W2095453603 startingPage "241" @default.
• W2095453603 abstract "BACKGROUND AND AIMS The interaction between cortisol and growth hormone (GH)-levels may significantly influence GH-responses to a stimulation test. In order to systematically analyse the interaction in a paired design, it is necessary to use a test, which has been proven safe and reliable such as the pyridostigmine-growth-hormone-releasing-hormone (PD-GHRH) test. Three groups of subjects with a different GH-secretory capacity were included. STUDY A Eight healthy adults were tested seven times, once with placebo throughout the examination and six times with the PD-GHRH test following no glucocorticoid pretreatment, pretreatment with hydrocortisone (HC) (30 mg/day and 80 mg/day for 1 and 3 days) or pretreatment with 15 mg prednisolone for 1 day. HC (80 mg/day for 1 day) in combination with PD significantly stimulated GH-levels compared to PD alone, 18.9 mU/l ± 6.1 vs 3.0 mU/l ± 0.8 (P < 0.05). However, peak GH-responses to PD in combination with GHRH were reduced during HC (80 mg/day for 1 day) compared to no glucocorticoid pretreatment in all healthy adults. Conventional HC therapy (30 mg/day for 1 and 3 days) did not significantly affect peak GH-responses. STUDY B 16 patients with suspected GH-deficiency (GHD) (seven with known ACTH-deficiency and nine with an intact pituitary-adrenal axis) were tested five times with the PD-GHRH test following no pretreatment or pretreatment with HC (30 mg/day and 80 mg/day for 1 and 3 days). Peak GH-responses were not significantly affected by conventional HC therapy (30 mg/day for 1 and 3 days). However, peak GH-responses to PD in combination with GHRH were reduced during HC (80 mg/day for 1 day) compared to no glucocorticoid pretreatment in all patients. Short-term hypocortisolism did not significantly affect peak GH-responses. CONCLUSION The GH-responses to a PD-GHRH test were reduced in all individuals during acute stress-appropriate cortisol levels and the percentage reduction in GH-levels was independent of the GH-secretory capacity. Clinically, we found that peak GH-responses were not significantly affected by a short break in conventional HC therapy nor by conventional HC therapy itself. However, our results also demonstrated that a GH-stimulation test should not be performed on patients, suffering from acute stress." @default.
• W2095453603 created "2016-06-24" @default.
• W2095453603 creator A5003072506 @default.
• W2095453603 creator A5027714891 @default.
• W2095453603 creator A5046096833 @default.
• W2095453603 creator A5077003976 @default.
• W2095453603 creator A5077029779 @default.
• W2095453603 date "1998-08-01" @default.
• W2095453603 modified "2023-09-24" @default.
• W2095453603 title "The effect of short-term cortisol changes on growth hormone responses to the pyridostigmine-growth-hormone-releasing-hormone test in healthy adults and patients with suspected growth hormone deficiency" @default.
• W2095453603 cites W1965916596 @default.
• W2095453603 cites W1966919723 @default.
• W2095453603 cites W1969893722 @default.
• W2095453603 cites W1971109849 @default.
• W2095453603 cites W1976108074 @default.
• W2095453603 cites W1978398243 @default.
• W2095453603 cites W1980800874 @default.
• W2095453603 cites W1983044920 @default.
• W2095453603 cites W1989382876 @default.
• W2095453603 cites W1993558710 @default.
• W2095453603 cites W1999389179 @default.
• W2095453603 cites W2005668937 @default.
• W2095453603 cites W2015795623 @default.
• W2095453603 cites W2016325781 @default.
• W2095453603 cites W2018958735 @default.
• W2095453603 cites W2023788363 @default.
• W2095453603 cites W2029717831 @default.
• W2095453603 cites W2049339524 @default.
• W2095453603 cites W2069123253 @default.
• W2095453603 cites W2069688139 @default.
• W2095453603 cites W2070652688 @default.
• W2095453603 cites W2076299594 @default.
• W2095453603 cites W2092962120 @default.
• W2095453603 cites W2106871977 @default.
• W2095453603 cites W2109986696 @default.
• W2095453603 cites W2118202495 @default.
• W2095453603 cites W2127635323 @default.
• W2095453603 cites W2150513416 @default.
• W2095453603 cites W2167919614 @default.
• W2095453603 cites W2318254865 @default.
• W2095453603 doi "https://doi.org/10.1046/j.1365-2265.1998.00529.x" @default.
• W2095453603 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9828914" @default.
• W2095453603 hasPublicationYear "1998" @default.
• W2095453603 type Work @default.
• W2095453603 sameAs 2095453603 @default.
• W2095453603 citedByCount "13" @default.
• W2095453603 countsByYear W20954536032015 @default.
• W2095453603 countsByYear W20954536032021 @default.
• W2095453603 crossrefType "journal-article" @default.
• W2095453603 hasAuthorship W2095453603A5003072506 @default.
• W2095453603 hasAuthorship W2095453603A5027714891 @default.
• W2095453603 hasAuthorship W2095453603A5046096833 @default.
• W2095453603 hasAuthorship W2095453603A5077003976 @default.
• W2095453603 hasAuthorship W2095453603A5077029779 @default.
• W2095453603 hasConcept C126322002 @default.
• W2095453603 hasConcept C134018914 @default.
• W2095453603 hasConcept C142724271 @default.
• W2095453603 hasConcept C204787440 @default.
• W2095453603 hasConcept C27081682 @default.
• W2095453603 hasConcept C2776715498 @default.
• W2095453603 hasConcept C2778105408 @default.
• W2095453603 hasConcept C2778709874 @default.
• W2095453603 hasConcept C2779901103 @default.
• W2095453603 hasConcept C2779952775 @default.
• W2095453603 hasConcept C2780841215 @default.
• W2095453603 hasConcept C2781042741 @default.
• W2095453603 hasConcept C2984496839 @default.
• W2095453603 hasConcept C71315377 @default.
• W2095453603 hasConcept C71924100 @default.
• W2095453603 hasConceptScore W2095453603C126322002 @default.
• W2095453603 hasConceptScore W2095453603C134018914 @default.
• W2095453603 hasConceptScore W2095453603C142724271 @default.
• W2095453603 hasConceptScore W2095453603C204787440 @default.
• W2095453603 hasConceptScore W2095453603C27081682 @default.
• W2095453603 hasConceptScore W2095453603C2776715498 @default.
• W2095453603 hasConceptScore W2095453603C2778105408 @default.
• W2095453603 hasConceptScore W2095453603C2778709874 @default.
• W2095453603 hasConceptScore W2095453603C2779901103 @default.
• W2095453603 hasConceptScore W2095453603C2779952775 @default.
• W2095453603 hasConceptScore W2095453603C2780841215 @default.
• W2095453603 hasConceptScore W2095453603C2781042741 @default.
• W2095453603 hasConceptScore W2095453603C2984496839 @default.
• W2095453603 hasConceptScore W2095453603C71315377 @default.
• W2095453603 hasConceptScore W2095453603C71924100 @default.
• W2095453603 hasIssue "2" @default.
• W2095453603 hasLocation W20954536031 @default.
• W2095453603 hasLocation W20954536032 @default.
• W2095453603 hasOpenAccess W2095453603 @default.
• W2095453603 hasPrimaryLocation W20954536031 @default.
• W2095453603 hasRelatedWork W1995003072 @default.
• W2095453603 hasRelatedWork W2020420628 @default.
• W2095453603 hasRelatedWork W2037744818 @default.
• W2095453603 hasRelatedWork W2069123253 @default.
• W2095453603 hasRelatedWork W2078337896 @default.
• W2095453603 hasRelatedWork W2084912383 @default.
• W2095453603 hasRelatedWork W2127738915 @default.
• W2095453603 hasRelatedWork W2135735583 @default.
• W2095453603 hasRelatedWork W2144329099 @default.

• next