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- W2095461294 abstract "The activity of hepatic microsomal cholesterol 7α-hydroxylase was studied in genetically obese and lean Zucker rats. The liver microsomal cholesterol 7α-hydroxylase activity in fatty Zucker rats (fafa) is about 50% to 70% lower than that of the lean (Fa/−) rats of the same sex, when animals were sacrificed at the middle of the dark cycle. When rats were sacrificed at the middle of the light cycle, cholesterol 7α-hydroxylase activity was the same as in the dark cycle in obese rats of both sexes, but was 65% lower in lean rats. However, cholesterol 7α-hydroxylase activity was stimulated by the treatment with cholestyramine in both obese and lean rats. Our results suggested that the diurnal regulation of cholesterol 7α-hydroxylase activity is lost in obese rats but was present under cholestyramine treatment in the genetically obese strain of rats." @default.
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- W2095461294 date "1988-01-01" @default.
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- W2095461294 title "Expression of hepatic microsomal cholesterol 7α-hydroxylase activity in lean and obese Zucker rats" @default.
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- W2095461294 doi "https://doi.org/10.1016/0006-291x(88)90470-6" @default.
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