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• W2095464003 abstract "Herpesviruses escape elimination by cytotoxic T lymphocytes through specific interference with the antigen-presenting function of MHC class I (MHC I) molecules. The transporter associated with antigen processing (TAP) forms a bottleneck in the MHC I antigen presentation pathway. The fact that multiple viruses, especially herpesviruses, encode molecules blocking TAP function is a case in point. The action of these viral immuno evasins is usually potent and very specific, making these proteins valuable tools for studying the cell biology of antigen presentation, including alternative antigen processing pathways. Yet, no dedicated TAP inhibitor has been described for any of the mouse herpesviruses. To permit the use of immuno evasins derived from non-mouse herpesviruses in mouse models, we assessed the cross-species activity of four TAP inhibitors and one tapasin inhibitor in the context of three different mouse haplotypes, H-2b, H-2d, and H-2k. Two of the four TAP inhibitors, the bovine herpesvirus 1-encoded UL49.5 and the human cytomegalovirus (HCMV)-encoded US6 protein, potently inhibited mouse TAP. ICP47 and BNLF2a, encoded by herpes simplexvirus 1 and Epstein–Barr virus, respectively, failed to inhibit TAP in all mouse cells tested. Previous work, however, demonstrated that US6 did not cross the mouse species barrier. We now show that substitution of the cysteine residue at position 108 was responsible for this lack of activity. The HCMV-encoded tapasin inhibitor US3 efficiently downregulated H-2d molecules on 3T3 cells, but not in other cell lines tested. Finally, we show that synthetic peptides comprising the functional domain of US6 can be exploited as a versatile TAP inhibitor. In conclusion, a complete overview is presented of the applicability of herpesvirus-encoded TAP and tapasin inhibitors in mouse cells of different genetic background." @default.
• W2095464003 created "2016-06-24" @default.
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• W2095464003 date "2011-03-01" @default.
• W2095464003 modified "2023-10-17" @default.
• W2095464003 title "Inhibition of mouse TAP by immune evasion molecules encoded by non-murine herpesviruses" @default.
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• W2095464003 cites W1517021800 @default.
• W2095464003 cites W1521491171 @default.
• W2095464003 cites W1572267688 @default.
• W2095464003 cites W1668110919 @default.
• W2095464003 cites W1883897672 @default.
• W2095464003 cites W1900551065 @default.
• W2095464003 cites W1976601347 @default.
• W2095464003 cites W1978518924 @default.
• W2095464003 cites W1979011182 @default.
• W2095464003 cites W1985495705 @default.
• W2095464003 cites W1987135006 @default.
• W2095464003 cites W1988097468 @default.
• W2095464003 cites W1993308255 @default.
• W2095464003 cites W1998535540 @default.
• W2095464003 cites W2010474050 @default.
• W2095464003 cites W2012237359 @default.
• W2095464003 cites W2018106813 @default.
• W2095464003 cites W2018841084 @default.
• W2095464003 cites W2023450134 @default.
• W2095464003 cites W2023967363 @default.
• W2095464003 cites W2026970642 @default.
• W2095464003 cites W2028898479 @default.
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• W2095464003 cites W2032818498 @default.
• W2095464003 cites W2033054937 @default.
• W2095464003 cites W2038363929 @default.
• W2095464003 cites W2045407060 @default.
• W2095464003 cites W2049882078 @default.
• W2095464003 cites W2051940153 @default.
• W2095464003 cites W2060736883 @default.
• W2095464003 cites W2061234769 @default.
• W2095464003 cites W2069624186 @default.
• W2095464003 cites W2071652768 @default.
• W2095464003 cites W2077906780 @default.
• W2095464003 cites W2078382230 @default.
• W2095464003 cites W2089251910 @default.
• W2095464003 cites W2089817347 @default.
• W2095464003 cites W2091792931 @default.
• W2095464003 cites W2098702227 @default.
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• W2095464003 cites W2130992969 @default.
• W2095464003 cites W2131000952 @default.
• W2095464003 cites W2136985879 @default.
• W2095464003 cites W2138103401 @default.
• W2095464003 cites W2140921627 @default.
• W2095464003 cites W2144526193 @default.
• W2095464003 cites W2144720739 @default.
• W2095464003 cites W2146898335 @default.
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• W2095464003 cites W2154720925 @default.
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• W2095464003 doi "https://doi.org/10.1016/j.molimm.2010.12.008" @default.
• W2095464003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21292324" @default.
• W2095464003 hasPublicationYear "2011" @default.
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