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• W2095465583 startingPage "1457" @default.
• W2095465583 abstract "In the mammalian central nervous system, responsiveness to glucocorticoids is mediated by both the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR). These pharmacologically distinct receptors are believed to bind to common response elements as homodimers. We provide evidence that MR and GR can form a heterodimeric complex with DNA-binding and transactivation properties different from those of the respective homodimers. There was a high degree of cooperativity of MR and GR in binding to a glucocorticoid response element. Transient transfection of a neuroblastoma cell line revealed a transcriptional response pattern of coexpressed MR and GR distinct from that obtained by MR or GR alone. Our findings demonstrate that heterodimerization of MR and GR is a hitherto unrecognized principle for the transcriptional regulation of glucocorti, coid-responsive genes in tissues coexpressing these receptors." @default.
• W2095465583 created "2016-06-24" @default.
• W2095465583 creator A5027159489 @default.
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• W2095465583 date "1994-12-01" @default.
• W2095465583 modified "2023-10-10" @default.
• W2095465583 title "Heterodimerization between mineralocorticoid and glucocorticoid receptor: A new principle of glucocorticoid action in the CNS" @default.
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• W2095465583 doi "https://doi.org/10.1016/0896-6273(94)90431-6" @default.
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