FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095466605> ?p ?o ?g. }

• W2095466605 endingPage "1184" @default.
• W2095466605 startingPage "1177" @default.
• W2095466605 abstract "Tumor cells, including colorectal cancer (CRC), are able to produce and release matrix metalloproteinase 9 (MMP-9) which is involved in tumor invasion and metastasis. Natural tissue inhibitors of matrix metalloproteinases (TIMPs) regulate activity of MMPs and stimulate tumor growth and malignant transformation. The aim of the present study was to compare the clinical significance of serum MMP-9 with TIMP-1 in the diagnosis of CRC patients and in the differentiation between colorectal adenoma (CA) and cancer. Serum MMP-9 and TIMP-1 were measured in 75 CRC patients, 35 CA, and 70 healthy subjects using enzyme-linked immunosorbent assay. Concentrations of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9) were determined by microparticle enzyme immunoassay. Serum levels of all proteins tested were significantly higher in CRC patients than in healthy subjects. Additionally, serum TIMP-1 was significantly higher in patients with CRC than in CA patients. Concentrations of TIMP-1 correlated with tumor stage, nodal involvement, presence of distant metastases, patients' survival, and tumor resectability. Diagnostic sensitivity of TIMP-1 was higher (61%) than those of other biomarkers (MMP-9, 55%; CEA, 39%; CA 19-9, 11%), and increased in combined use with MMP-9 (75%) or CEA (73%). The areas under receiver operating characteristic curves of TIMP-1 were larger than those of MMP-9. Our findings suggest better usefulness of serum TIMP-1 than MMP-9 in the diagnosis of CRC, especially in the assessment of Duke's classification of tumor stage, survival of cancer patients, resectability of tumor, and in the differentiation between CA and cancer." @default.
• W2095466605 created "2016-06-24" @default.
• W2095466605 creator A5010032121 @default.
• W2095466605 creator A5031419790 @default.
• W2095466605 creator A5061203371 @default.
• W2095466605 creator A5071565595 @default.
• W2095466605 creator A5083032601 @default.
• W2095466605 date "2010-06-17" @default.
• W2095466605 modified "2023-09-25" @default.
• W2095466605 title "The diagnostic value of matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of matrix metalloproteinases 1 (TIMP-1) determination in the sera of colorectal adenoma and cancer patients" @default.
• W2095466605 cites W1482004139 @default.
• W2095466605 cites W1895814476 @default.
• W2095466605 cites W1963681491 @default.
• W2095466605 cites W1965434005 @default.
• W2095466605 cites W1967417677 @default.
• W2095466605 cites W1969688281 @default.
• W2095466605 cites W1971343559 @default.
• W2095466605 cites W1973655873 @default.
• W2095466605 cites W1979022007 @default.
• W2095466605 cites W1999018281 @default.
• W2095466605 cites W2001258296 @default.
• W2095466605 cites W2020328564 @default.
• W2095466605 cites W2029638350 @default.
• W2095466605 cites W2035548685 @default.
• W2095466605 cites W2037910534 @default.
• W2095466605 cites W2052280647 @default.
• W2095466605 cites W2083143922 @default.
• W2095466605 cites W2101995865 @default.
• W2095466605 cites W2120320390 @default.
• W2095466605 cites W2128601920 @default.
• W2095466605 cites W2153321407 @default.
• W2095466605 cites W2166277557 @default.
• W2095466605 cites W3024113572 @default.
• W2095466605 cites W4244893411 @default.
• W2095466605 doi "https://doi.org/10.1007/s00384-010-0991-9" @default.
• W2095466605 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2928442" @default.
• W2095466605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20556397" @default.
• W2095466605 hasPublicationYear "2010" @default.
• W2095466605 type Work @default.
• W2095466605 sameAs 2095466605 @default.
• W2095466605 citedByCount "57" @default.
• W2095466605 countsByYear W20954666052012 @default.
• W2095466605 countsByYear W20954666052013 @default.
• W2095466605 countsByYear W20954666052014 @default.
• W2095466605 countsByYear W20954666052015 @default.
• W2095466605 countsByYear W20954666052016 @default.
• W2095466605 countsByYear W20954666052017 @default.
• W2095466605 countsByYear W20954666052018 @default.
• W2095466605 countsByYear W20954666052019 @default.
• W2095466605 countsByYear W20954666052020 @default.
• W2095466605 countsByYear W20954666052021 @default.
• W2095466605 countsByYear W20954666052022 @default.
• W2095466605 countsByYear W20954666052023 @default.
• W2095466605 crossrefType "journal-article" @default.
• W2095466605 hasAuthorship W2095466605A5010032121 @default.
• W2095466605 hasAuthorship W2095466605A5031419790 @default.
• W2095466605 hasAuthorship W2095466605A5061203371 @default.
• W2095466605 hasAuthorship W2095466605A5071565595 @default.
• W2095466605 hasAuthorship W2095466605A5083032601 @default.
• W2095466605 hasBestOaLocation W20954666051 @default.
• W2095466605 hasConcept C109523444 @default.
• W2095466605 hasConcept C121608353 @default.
• W2095466605 hasConcept C126322002 @default.
• W2095466605 hasConcept C142724271 @default.
• W2095466605 hasConcept C143998085 @default.
• W2095466605 hasConcept C146357865 @default.
• W2095466605 hasConcept C151730666 @default.
• W2095466605 hasConcept C159654299 @default.
• W2095466605 hasConcept C203014093 @default.
• W2095466605 hasConcept C2775965246 @default.
• W2095466605 hasConcept C2777387746 @default.
• W2095466605 hasConcept C2779013556 @default.
• W2095466605 hasConcept C2780420688 @default.
• W2095466605 hasConcept C2781447364 @default.
• W2095466605 hasConcept C526805850 @default.
• W2095466605 hasConcept C71924100 @default.
• W2095466605 hasConcept C86803240 @default.
• W2095466605 hasConcept C90924648 @default.
• W2095466605 hasConceptScore W2095466605C109523444 @default.
• W2095466605 hasConceptScore W2095466605C121608353 @default.
• W2095466605 hasConceptScore W2095466605C126322002 @default.
• W2095466605 hasConceptScore W2095466605C142724271 @default.
• W2095466605 hasConceptScore W2095466605C143998085 @default.
• W2095466605 hasConceptScore W2095466605C146357865 @default.
• W2095466605 hasConceptScore W2095466605C151730666 @default.
• W2095466605 hasConceptScore W2095466605C159654299 @default.
• W2095466605 hasConceptScore W2095466605C203014093 @default.
• W2095466605 hasConceptScore W2095466605C2775965246 @default.
• W2095466605 hasConceptScore W2095466605C2777387746 @default.
• W2095466605 hasConceptScore W2095466605C2779013556 @default.
• W2095466605 hasConceptScore W2095466605C2780420688 @default.
• W2095466605 hasConceptScore W2095466605C2781447364 @default.
• W2095466605 hasConceptScore W2095466605C526805850 @default.
• W2095466605 hasConceptScore W2095466605C71924100 @default.
• W2095466605 hasConceptScore W2095466605C86803240 @default.
• W2095466605 hasConceptScore W2095466605C90924648 @default.
• W2095466605 hasIssue "10" @default.
• W2095466605 hasLocation W20954666051 @default.

• next