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- W2095467035 abstract "Choline molecules are needed for the synthesis of acetylcholine and phospholipids in the mammalian brain. An enzymatic activity capable of forming lecithin (phosphatidylcholine) from the step-by-step methylation of phosphatidylethanolamine is identified in the bovine brain. This enzyme(s), phosphatidylethanolamine-N-methyltransferase (EC 2.1.1.17), is localized in the synaptosomal fraction of bovine caudate nucleus, uses S-adenosylmethionine as the methyl donor (apparent Km = 20 μM), and has a Vmax of 50–60 pmol/mg protein × h (i.e. about 1% of that found in rat liver). The brain may be able to meet some of its choline requirements by de novo synthesis." @default.
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- W2095467035 date "1979-12-01" @default.
- W2095467035 modified "2023-10-17" @default.
- W2095467035 title "Synthesis of lecithin (phosphatidylcholine) from phosphatidylethanolamine in bovine brain" @default.
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- W2095467035 doi "https://doi.org/10.1016/0006-8993(79)90447-5" @default.
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