FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095480767> ?p ?o ?g. }

• W2095480767 endingPage "2373" @default.
• W2095480767 startingPage "2367" @default.
• W2095480767 abstract "High-mannose N -linked glycans recognized by carbohydrate-binding agents (CBAs) are potential targets for topical microbicides. To better understand the mechanisms by which CBAs inhibit human immunodeficiency virus (HIV)-1 infection at the molecular level, we systematically analysed the contribution of site-specific glycans to the anti-HIV activity of CBAs by site-directed mutagenesis. Our results demonstrate that a single deglycosylation at N295 or N448 in a range of primary and T-cell-line-adapted HIV-1 isolates resulted in marked resistance to griffithsin (GRFT) but maintained the sensitivity to cyanovirin (CV-N), Galanthus nivalis agglutinin (GNA) and a range of neutralizing antibodies. Unlike CV-N and GNA, the interaction between GRFT and gp120 appeared to be dependent on the specific trimeric ‘sugar tower’ including N295 and N448. This was further strengthened by the results of GRFT–Env binding experiments. Our study identifies GRFT-specific gp120 glycans and may provide information for the design of novel CBA antiviral strategies." @default.
• W2095480767 created "2016-06-24" @default.
• W2095480767 creator A5062211610 @default.
• W2095480767 creator A5066602405 @default.
• W2095480767 creator A5077459413 @default.
• W2095480767 creator A5083473331 @default.
• W2095480767 creator A5086956796 @default.
• W2095480767 date "2011-10-01" @default.
• W2095480767 modified "2023-09-27" @default.
• W2095480767 title "Removal of two high-mannose N-linked glycans on gp120 renders human immunodeficiency virus 1 largely resistant to the carbohydrate-binding agent griffithsin" @default.
• W2095480767 cites W1505517942 @default.
• W2095480767 cites W1628484047 @default.
• W2095480767 cites W1982769349 @default.
• W2095480767 cites W1985711808 @default.
• W2095480767 cites W1988784338 @default.
• W2095480767 cites W1997677784 @default.
• W2095480767 cites W2002662064 @default.
• W2095480767 cites W2005963291 @default.
• W2095480767 cites W2020465880 @default.
• W2095480767 cites W2032091598 @default.
• W2095480767 cites W2042476299 @default.
• W2095480767 cites W2070707998 @default.
• W2095480767 cites W2079028174 @default.
• W2095480767 cites W2085378807 @default.
• W2095480767 cites W2085618698 @default.
• W2095480767 cites W2094673047 @default.
• W2095480767 cites W2098781795 @default.
• W2095480767 cites W2102090534 @default.
• W2095480767 cites W2109471408 @default.
• W2095480767 cites W2115059789 @default.
• W2095480767 cites W2117307765 @default.
• W2095480767 cites W2128069859 @default.
• W2095480767 cites W2138802639 @default.
• W2095480767 cites W2141444589 @default.
• W2095480767 cites W2152433082 @default.
• W2095480767 cites W2154097024 @default.
• W2095480767 cites W2156764168 @default.
• W2095480767 cites W2163558461 @default.
• W2095480767 cites W2170748261 @default.
• W2095480767 cites W2171700985 @default.
• W2095480767 cites W2172063653 @default.
• W2095480767 cites W2416039323 @default.
• W2095480767 doi "https://doi.org/10.1099/vir.0.033092-0" @default.
• W2095480767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21715597" @default.
• W2095480767 hasPublicationYear "2011" @default.
• W2095480767 type Work @default.
• W2095480767 sameAs 2095480767 @default.
• W2095480767 citedByCount "33" @default.
• W2095480767 countsByYear W20954807672012 @default.
• W2095480767 countsByYear W20954807672013 @default.
• W2095480767 countsByYear W20954807672014 @default.
• W2095480767 countsByYear W20954807672015 @default.
• W2095480767 countsByYear W20954807672016 @default.
• W2095480767 countsByYear W20954807672018 @default.
• W2095480767 countsByYear W20954807672019 @default.
• W2095480767 countsByYear W20954807672020 @default.
• W2095480767 countsByYear W20954807672021 @default.
• W2095480767 crossrefType "journal-article" @default.
• W2095480767 hasAuthorship W2095480767A5062211610 @default.
• W2095480767 hasAuthorship W2095480767A5066602405 @default.
• W2095480767 hasAuthorship W2095480767A5077459413 @default.
• W2095480767 hasAuthorship W2095480767A5083473331 @default.
• W2095480767 hasAuthorship W2095480767A5086956796 @default.
• W2095480767 hasBestOaLocation W20954807671 @default.
• W2095480767 hasConcept C104317684 @default.
• W2095480767 hasConcept C108625454 @default.
• W2095480767 hasConcept C153911025 @default.
• W2095480767 hasConcept C159047783 @default.
• W2095480767 hasConcept C159654299 @default.
• W2095480767 hasConcept C16318435 @default.
• W2095480767 hasConcept C203014093 @default.
• W2095480767 hasConcept C206212055 @default.
• W2095480767 hasConcept C2775887612 @default.
• W2095480767 hasConcept C2778977261 @default.
• W2095480767 hasConcept C501734568 @default.
• W2095480767 hasConcept C55493867 @default.
• W2095480767 hasConcept C86803240 @default.
• W2095480767 hasConceptScore W2095480767C104317684 @default.
• W2095480767 hasConceptScore W2095480767C108625454 @default.
• W2095480767 hasConceptScore W2095480767C153911025 @default.
• W2095480767 hasConceptScore W2095480767C159047783 @default.
• W2095480767 hasConceptScore W2095480767C159654299 @default.
• W2095480767 hasConceptScore W2095480767C16318435 @default.
• W2095480767 hasConceptScore W2095480767C203014093 @default.
• W2095480767 hasConceptScore W2095480767C206212055 @default.
• W2095480767 hasConceptScore W2095480767C2775887612 @default.
• W2095480767 hasConceptScore W2095480767C2778977261 @default.
• W2095480767 hasConceptScore W2095480767C501734568 @default.
• W2095480767 hasConceptScore W2095480767C55493867 @default.
• W2095480767 hasConceptScore W2095480767C86803240 @default.
• W2095480767 hasIssue "10" @default.
• W2095480767 hasLocation W20954807671 @default.
• W2095480767 hasLocation W20954807672 @default.
• W2095480767 hasOpenAccess W2095480767 @default.
• W2095480767 hasPrimaryLocation W20954807671 @default.
• W2095480767 hasRelatedWork W1483932958 @default.
• W2095480767 hasRelatedWork W1693086232 @default.
• W2095480767 hasRelatedWork W1981905369 @default.

• next