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• W2095482617 abstract "siRNA is promising in anti-tumor therapy. The main challenge is lack of tumor-specific intracellular delivery. In this study, a 6 amino acids peptide (A1) with high affinity for vascular endothelial growth factor receptor-1 (VEGFR1) was conjugated with a cell penetrating peptide (CPP) TAT to form a tumor-selective CPP. To evaluate the tumor-targeted penetrate property of TAT-A1, the uptake of TAT-A1 was measured by flow cytometry. The selectivity in vitro was tested in co-cultured tumor cells and normal cells by laser confocal microscope. The internalization efficiency of TAT-A1 was significantly higher than that of TAT (p < 0.05). TAT-A1 penetrated into tumor cells selectively when added to co-cultured tumor cells and normal cells due to the recognition of VEGFR1 which is over-expressed on tumor cells. Furthermore, siRNA was successfully transferred by TAT-A1 into tumor cells in a similar way of Lipofectamine 2000, which was proved to be an efficient vector. The knockout effect of siRNA transferred by TAT-A1 was obtained at both mRNA and protein level. These results indicated that the tumor-targeted TAT-A1 can act as an excellent vehicle for specific delivery of anti-cancer agents." @default.
• W2095482617 created "2016-06-24" @default.
• W2095482617 creator A5014134138 @default.
• W2095482617 creator A5051746700 @default.
• W2095482617 creator A5053863947 @default.
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• W2095482617 date "2013-02-01" @default.
• W2095482617 modified "2023-10-17" @default.
• W2095482617 title "A novel cell-penetrating peptide TAT-A1 delivers siRNA into tumor cells selectively" @default.
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• W2095482617 doi "https://doi.org/10.1016/j.biochi.2012.09.020" @default.
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• W2095482617 hasPublicationYear "2013" @default.
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