Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095482923> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2095482923 endingPage "634" @default.
- W2095482923 startingPage "634" @default.
- W2095482923 abstract "5 girls with true PP (4-8 years), demonstrating clinical signs of puberty, accelerated growth velocity, advanced bone age and pubertal LH/FSH levels of gonadotrophins, were treated with an intranasal spray of the LH-RH-analogue D-Ser (TBU)6-LH-RH-EA (Buserelin (B)) for 6 to 9 months. Therapy was started with 8×300 μg B/day intranasally (150 μg per puff into each nostril) for 2 weeks, followed by a maintenance dose of 3×300 μg/day.When spontaneous LH/FSH-secretion during the night (20 min.sampling intervals from 0 to 4 a.m.) before and 7 days after beginning of the treatment was compared, 2 girls showed a slight rise of median LH values (3.5 to 6.5 mIU/ml) and to others a decrease (18 to 9 mIU/ml). Only one had 2 spontaneous bursts of secretion that did not occur on B-therapy one week later. Whereas measurements of LH/FSH, E2 and testosterone after 1, 3, 6 and 9 months of B-treatment suggested continued suppression of the pituitary-gonadal axis, adrenal steroids (DHEA-S) did not change. Clinical signs of puberty were diminished or arrested, including the acceleration of skeletal maturation. Clinical or endocrinological escape phenomena were not observed. Intranasal application of B, therefore, compares favorably to other form of PP-therapy." @default.
- W2095482923 created "2016-06-24" @default.
- W2095482923 creator A5009583953 @default.
- W2095482923 creator A5012458532 @default.
- W2095482923 creator A5021715204 @default.
- W2095482923 creator A5084366876 @default.
- W2095482923 creator A5087742173 @default.
- W2095482923 date "1985-06-01" @default.
- W2095482923 modified "2023-09-27" @default.
- W2095482923 title "187 INTRANASAL TREATMENT OF PRECOCIOUS PUBERTY (PP) WITH A LONG-ACTING LH-RH-ANALOGUE" @default.
- W2095482923 doi "https://doi.org/10.1203/00006450-198506000-00207" @default.
- W2095482923 hasPublicationYear "1985" @default.
- W2095482923 type Work @default.
- W2095482923 sameAs 2095482923 @default.
- W2095482923 citedByCount "2" @default.
- W2095482923 crossrefType "journal-article" @default.
- W2095482923 hasAuthorship W2095482923A5009583953 @default.
- W2095482923 hasAuthorship W2095482923A5012458532 @default.
- W2095482923 hasAuthorship W2095482923A5021715204 @default.
- W2095482923 hasAuthorship W2095482923A5084366876 @default.
- W2095482923 hasAuthorship W2095482923A5087742173 @default.
- W2095482923 hasBestOaLocation W20954829231 @default.
- W2095482923 hasConcept C126322002 @default.
- W2095482923 hasConcept C134018914 @default.
- W2095482923 hasConcept C141071460 @default.
- W2095482923 hasConcept C170493617 @default.
- W2095482923 hasConcept C2776354409 @default.
- W2095482923 hasConcept C2777230143 @default.
- W2095482923 hasConcept C2778311950 @default.
- W2095482923 hasConcept C2778367240 @default.
- W2095482923 hasConcept C2778938600 @default.
- W2095482923 hasConcept C2779279991 @default.
- W2095482923 hasConcept C2779789940 @default.
- W2095482923 hasConcept C2780973058 @default.
- W2095482923 hasConcept C71315377 @default.
- W2095482923 hasConcept C71924100 @default.
- W2095482923 hasConcept C85663871 @default.
- W2095482923 hasConcept C89551170 @default.
- W2095482923 hasConcept C98274493 @default.
- W2095482923 hasConceptScore W2095482923C126322002 @default.
- W2095482923 hasConceptScore W2095482923C134018914 @default.
- W2095482923 hasConceptScore W2095482923C141071460 @default.
- W2095482923 hasConceptScore W2095482923C170493617 @default.
- W2095482923 hasConceptScore W2095482923C2776354409 @default.
- W2095482923 hasConceptScore W2095482923C2777230143 @default.
- W2095482923 hasConceptScore W2095482923C2778311950 @default.
- W2095482923 hasConceptScore W2095482923C2778367240 @default.
- W2095482923 hasConceptScore W2095482923C2778938600 @default.
- W2095482923 hasConceptScore W2095482923C2779279991 @default.
- W2095482923 hasConceptScore W2095482923C2779789940 @default.
- W2095482923 hasConceptScore W2095482923C2780973058 @default.
- W2095482923 hasConceptScore W2095482923C71315377 @default.
- W2095482923 hasConceptScore W2095482923C71924100 @default.
- W2095482923 hasConceptScore W2095482923C85663871 @default.
- W2095482923 hasConceptScore W2095482923C89551170 @default.
- W2095482923 hasConceptScore W2095482923C98274493 @default.
- W2095482923 hasIssue "6" @default.
- W2095482923 hasLocation W20954829231 @default.
- W2095482923 hasOpenAccess W2095482923 @default.
- W2095482923 hasPrimaryLocation W20954829231 @default.
- W2095482923 hasRelatedWork W1969458283 @default.
- W2095482923 hasRelatedWork W1985732893 @default.
- W2095482923 hasRelatedWork W1990734846 @default.
- W2095482923 hasRelatedWork W1995163599 @default.
- W2095482923 hasRelatedWork W2068647729 @default.
- W2095482923 hasRelatedWork W2095482923 @default.
- W2095482923 hasRelatedWork W2112835642 @default.
- W2095482923 hasRelatedWork W2142416343 @default.
- W2095482923 hasRelatedWork W2144189739 @default.
- W2095482923 hasRelatedWork W2157645473 @default.
- W2095482923 hasVolume "19" @default.
- W2095482923 isParatext "false" @default.
- W2095482923 isRetracted "false" @default.
- W2095482923 magId "2095482923" @default.
- W2095482923 workType "article" @default.