FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095484080> ?p ?o ?g. }

• W2095484080 endingPage "110" @default.
• W2095484080 startingPage "102" @default.
• W2095484080 abstract "Workplace exposures to mixtures of nickel compounds have been associated with excess respiratory cancer risk. Animal studies with individual nickel compounds indicate that not all nickel substances have the same potency or potential to induce tumors. The bioavailability of nickel ions at critical cellular sites seems to be important to determine the potential of a substance to induce tumors in animals, but much less is understood about the exact nature (genotoxic or non-genotoxic) of the nickel effects. Within many regulatory frameworks (e.g., European Union), substances are classified for mutagenicity based on the available data and this classification will often influence the mode of action assigned to carcinogenic substances and the way in which risk assessment will be conducted. The objective of this study was to evaluate the ability of nickel sulfate hexahydrate to induce micronuclei in polychromatic erythrocytes (PCEs) in rat bone marrow. This study was conducted according to OECD and EU protocol guidelines. In the dose range-finding assays, the maximum tolerated dose was estimated to be 500 mg/kg/day. The doses used in the micronucleus assay were 125, 250, and 500 mg/kg/day. At least 2000 PCEs per animal were analyzed for micronuclei in PCEs. Cytotoxicity was assessed by scoring a minimum of 500 consecutive total polychromatic (PCE) and normochromatic (NCE) erythrocytes (PCE/NCE ratio). Nickel sulfate hexahydrate did not induce statistically significant increases in micronucleated PCEs at any dose examined. The negative results in the present study contribute significantly to the weight of evidence evaluation of the mutagenicity (chromosomal level) of nickel substances. These results are consistent with a non-genotoxic mode of action for soluble nickel that could explain the enhancement of cancer risk seen among refinery workers with mixed exposures and its lack of carcinogenicity in animal studies with single exposures." @default.
• W2095484080 created "2016-06-24" @default.
• W2095484080 creator A5042861053 @default.
• W2095484080 creator A5054884395 @default.
• W2095484080 date "2007-01-01" @default.
• W2095484080 modified "2023-10-09" @default.
• W2095484080 title "Lack of micronuclei formation in bone marrow of rats after repeated oral exposure to nickel sulfate hexahydrate" @default.
• W2095484080 cites W1981938697 @default.
• W2095484080 cites W1989977597 @default.
• W2095484080 cites W1997329790 @default.
• W2095484080 cites W2004120671 @default.
• W2095484080 cites W2015767573 @default.
• W2095484080 cites W2033007351 @default.
• W2095484080 cites W2040143609 @default.
• W2095484080 cites W2040979540 @default.
• W2095484080 cites W2049978718 @default.
• W2095484080 cites W2053855895 @default.
• W2095484080 cites W2054587699 @default.
• W2095484080 cites W2062607371 @default.
• W2095484080 cites W2063462137 @default.
• W2095484080 cites W2069438184 @default.
• W2095484080 cites W2076638855 @default.
• W2095484080 cites W2084157754 @default.
• W2095484080 cites W2086917819 @default.
• W2095484080 cites W2091929159 @default.
• W2095484080 cites W2101388750 @default.
• W2095484080 cites W2110732081 @default.
• W2095484080 cites W2117527562 @default.
• W2095484080 cites W2131604077 @default.
• W2095484080 cites W2140913594 @default.
• W2095484080 cites W2170445850 @default.
• W2095484080 cites W4254945848 @default.
• W2095484080 cites W4300209331 @default.
• W2095484080 doi "https://doi.org/10.1016/j.mrgentox.2006.09.001" @default.
• W2095484080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17052950" @default.
• W2095484080 hasPublicationYear "2007" @default.
• W2095484080 type Work @default.
• W2095484080 sameAs 2095484080 @default.
• W2095484080 citedByCount "20" @default.
• W2095484080 countsByYear W20954840802012 @default.
• W2095484080 countsByYear W20954840802014 @default.
• W2095484080 countsByYear W20954840802015 @default.
• W2095484080 countsByYear W20954840802017 @default.
• W2095484080 countsByYear W20954840802019 @default.
• W2095484080 countsByYear W20954840802020 @default.
• W2095484080 countsByYear W20954840802022 @default.
• W2095484080 crossrefType "journal-article" @default.
• W2095484080 hasAuthorship W2095484080A5042861053 @default.
• W2095484080 hasAuthorship W2095484080A5054884395 @default.
• W2095484080 hasConcept C105639569 @default.
• W2095484080 hasConcept C114246631 @default.
• W2095484080 hasConcept C144133560 @default.
• W2095484080 hasConcept C178790620 @default.
• W2095484080 hasConcept C181389837 @default.
• W2095484080 hasConcept C185592680 @default.
• W2095484080 hasConcept C202751555 @default.
• W2095484080 hasConcept C2778343803 @default.
• W2095484080 hasConcept C2778959862 @default.
• W2095484080 hasConcept C2910001868 @default.
• W2095484080 hasConcept C29730261 @default.
• W2095484080 hasConcept C33070731 @default.
• W2095484080 hasConcept C36681516 @default.
• W2095484080 hasConcept C45080847 @default.
• W2095484080 hasConcept C504270822 @default.
• W2095484080 hasConcept C55493867 @default.
• W2095484080 hasConcept C57992300 @default.
• W2095484080 hasConcept C71924100 @default.
• W2095484080 hasConcept C86803240 @default.
• W2095484080 hasConcept C98274493 @default.
• W2095484080 hasConceptScore W2095484080C105639569 @default.
• W2095484080 hasConceptScore W2095484080C114246631 @default.
• W2095484080 hasConceptScore W2095484080C144133560 @default.
• W2095484080 hasConceptScore W2095484080C178790620 @default.
• W2095484080 hasConceptScore W2095484080C181389837 @default.
• W2095484080 hasConceptScore W2095484080C185592680 @default.
• W2095484080 hasConceptScore W2095484080C202751555 @default.
• W2095484080 hasConceptScore W2095484080C2778343803 @default.
• W2095484080 hasConceptScore W2095484080C2778959862 @default.
• W2095484080 hasConceptScore W2095484080C2910001868 @default.
• W2095484080 hasConceptScore W2095484080C29730261 @default.
• W2095484080 hasConceptScore W2095484080C33070731 @default.
• W2095484080 hasConceptScore W2095484080C36681516 @default.
• W2095484080 hasConceptScore W2095484080C45080847 @default.
• W2095484080 hasConceptScore W2095484080C504270822 @default.
• W2095484080 hasConceptScore W2095484080C55493867 @default.
• W2095484080 hasConceptScore W2095484080C57992300 @default.
• W2095484080 hasConceptScore W2095484080C71924100 @default.
• W2095484080 hasConceptScore W2095484080C86803240 @default.
• W2095484080 hasConceptScore W2095484080C98274493 @default.
• W2095484080 hasIssue "1-2" @default.
• W2095484080 hasLocation W20954840801 @default.
• W2095484080 hasLocation W20954840802 @default.
• W2095484080 hasOpenAccess W2095484080 @default.
• W2095484080 hasPrimaryLocation W20954840801 @default.
• W2095484080 hasRelatedWork W1888660086 @default.
• W2095484080 hasRelatedWork W1969438236 @default.
• W2095484080 hasRelatedWork W2000979784 @default.
• W2095484080 hasRelatedWork W2007201782 @default.

• next