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• W2095486519 abstract "This study investigated T-cell activation markers HLA-DR and CD69 in both naive (CD45RA+) and memory (CD45RA−) CD4+as well as CD8+T cells in peripheral blood of patients with autoimmune thyroiditis (AT,N= 28) or hyperthyroid untreated Graves’ disease (GDH,N= 34) using three-color flow cytometry. It was demonstrated that patients with AT, but not those with GDH, expressed increased amounts of HLA-DR antigen compared to healthy subjects (HS,N= 26) on total CD4+(AT: 14.1%; GDH: 11.3%; HS: 10.9%) and CD8+cells (AT: 31.9%; GDH: 23.5%; HS: 19.4%) as well as on CD45RA−CD4+cells (AT: 11.2%; GDH: 7.7%; HS: 7.9%). In GDH (+71%) and AT (+91%) only the proportion of HLA-DR+CD45RA+CD8+cells was increased vs HS. Furthermore, euthyroid GD patients on methimazole (GDE,N= 22) displayed greater HLA-DR+expression on total and CD45RA−cells within both CD4+(+37 and 40%, respectively) and CD8+cells (+47 and 93%, respectively) than GDH. In addition, total and CD45RA+CD4+and CD8+cells were increased vs HS. In contrast, proportions of CD69 positive T cells were increased in AT and GDH on total CD4+(+97 and 74%, respectively) and CD8+(+95 and 68%, respectively) cells and all subsets thereof (except for CD45RA−cells in GDH), but normalized upon thyrostatic treatment. We conclude that patients with autoimmune thyroid disease harbor an almost twofold greater proportion vs HS of (a) HLA-DR+CD45RA+CD8+T cells, and of (b) CD69 on total CD4+and CD8+cells, and an even more marked elevation on their CD45RA+subset in AT and untreated GD. In addition, (c) thyrostatic treatment by methimazole in GD is accompanied by a further increase in circulating HLA-DR+CD4+and CD8+cells and their CD45RA−subsets, but decreased CD69 expression. These data suggest association of HLA-DR expression with ongoing autoimmunity, while increased CD69 expression relates in part also to elevated thyroid hormone concentration in GDH." @default.
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• W2095486519 date "1998-05-01" @default.
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• W2095486519 title "Elevated CD69 Expression on Naive Peripheral Blood T-Cells in Hyperthyroid Graves’ Disease and Autoimmune Thyroiditis: Discordant Effect of Methimazole on HLA-DR and CD69" @default.
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• W2095486519 doi "https://doi.org/10.1006/clin.1998.4524" @default.
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