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- W2095487071 abstract "A small dose of ephedrine decreases the onset time of rocuronium and cisatracurium; however, ephedrine might be associated with adverse hemodynamic effects. The appropriate dose of ephedrine has not been determined. We, therefore, studied 120 patients anesthetized with fentanyl 2 μg/kg and propofol 2–2.5 mg/kg who were randomly divided to receive either ephedrine (30, 70, or 110 μg/kg) or saline. During propofol anesthesia, the neuromuscular block was monitored by mechanomyography by using submaximal current of train-of-four stimulation every 10 s. To determine cardiac output, a transcutaneous Doppler probe was placed externally at the suprasternal notch. Tracheal intubation was performed by a blinded investigator at 2 min after vecuronium. Neuromuscular block, intubating conditions, and hemodynamic effects were measured during the induction of anesthesia. Both ephedrine 70 and 110 μg/kg improved intubating conditions at 2 min after vecuronium; however, 110 μg/kg was associated with adverse hemodynamic effects. We conclude that ephedrine 70 μg/kg given before the induction of anesthesia improved intubating conditions at 2 min after vecuronium, probably by increased cardiac output without significant adverse hemodynamic effects." @default.
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- W2095487071 date "2003-04-01" @default.
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- W2095487071 title "The Dose Effect of Ephedrine on the Onset Time of Vecuronium" @default.
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- W2095487071 doi "https://doi.org/10.1213/01.ane.0000034551.93647.3a" @default.
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