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• W2095493405 abstract "Serotonin (5-HT), norepinephrine and orexins (ORX) are the three best established mediators of wake-related activation of hypoglossal (XII) motoneurons that innervate the muscles of the tongue. Since the tongue's use is temporarily closely aligned with the rest–activity cycle, we tested whether expression of mRNA for relevant 5-HT, norepinephrine and ORX receptors varies in the XII nucleus with the rest–activity cycle. Adult rats (n = 7–9/group) were decapitated at 8–9 am (near rest period onset) or at 6–7 pm (near active period onset). Tissue micropunches were extracted from medullary slices containing the XII motor and sensory external cuneate (ECN) nuclei. 5-HT2A, α1-adrenergic and ORX type 2 receptor mRNAs were quantified using RT-PCR. Only 5-HT2A receptor mRNA levels differed between the two time points and were higher at the active period onset; no differences were detected in the ECN. Consistent with the mRNA results, 5-HT2A protein levels were also higher in the XII nucleus at the active period onset than at rest onset. Thus, the endogenous serotonergic excitatory drive to XII motoneurons may be enhanced through circadian- or activity-dependent mechanisms that increase the availability of 5-HT2A receptors prior to the active period. Conversely, reduced levels of 5-HT2A receptors during the rest–sleep period may exacerbate the propensity for sleep-disordered breathing in subjects with anatomically compromised upper airway." @default.
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• W2095493405 date "2013-09-01" @default.
• W2095493405 modified "2023-09-27" @default.
• W2095493405 title "Circadian dependence of receptors that mediate wake-related excitatory drive to hypoglossal motoneurons" @default.
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• W2095493405 doi "https://doi.org/10.1016/j.resp.2013.04.024" @default.
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