FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095498603> ?p ?o ?g. }

• W2095498603 endingPage "1819" @default.
• W2095498603 startingPage "1811" @default.
• W2095498603 abstract "Molecular modeling studies using the CHARMM method have been conducted to study the binding modes of aldose reductase inhibitors at the active site of aldose reductase. The energy minimized structures of aldose reductase with six structurally diverse inhibitors (spirofluorene-9,5'-imidazolidine-2',4'-dione (1), 9-fluoreneacetic acid (2), AL1576 (3), 2,7-difluoro-9-fluoreneacetic acid (4), FK366 (5), and Epalrestat (9)) indicate that the side chains of Tyr48, His110, and Trp111 can form numerous hydrogen bonds with either the carboxylate or the hydantoin group of the inhibitors while the side chains of Trp20, Trp111, and Phe122 are positioned to form aromatic-aromatic interactions. Of the three residues (Tyr 48, His 110, and Trp 111) that can form hydrogen bonds with the ionized portion of aldose reductase inhibitors, protonated His110 appears to play an important role in directing charged inhibitors to bind at the active site through charge interaction. Based on the binding mode of the inhibitors and their observed inhibitory activities, pharmacophore requirements for aldose reductase inhibitors are discussed." @default.
• W2095498603 created "2016-06-24" @default.
• W2095498603 creator A5013346862 @default.
• W2095498603 creator A5040290706 @default.
• W2095498603 creator A5085399923 @default.
• W2095498603 date "1998-10-01" @default.
• W2095498603 modified "2023-09-27" @default.
• W2095498603 title "Molecular modeling studies of the binding modes of aldose reductase inhibitors at the active site of human aldose reductase" @default.
• W2095498603 cites W1965039913 @default.
• W2095498603 cites W1969080191 @default.
• W2095498603 cites W1971853219 @default.
• W2095498603 cites W1973039222 @default.
• W2095498603 cites W1974361942 @default.
• W2095498603 cites W1978762651 @default.
• W2095498603 cites W1982189115 @default.
• W2095498603 cites W1987664448 @default.
• W2095498603 cites W1988662281 @default.
• W2095498603 cites W2004014072 @default.
• W2095498603 cites W2006935259 @default.
• W2095498603 cites W2010237332 @default.
• W2095498603 cites W2013901674 @default.
• W2095498603 cites W2015801482 @default.
• W2095498603 cites W2019293938 @default.
• W2095498603 cites W2025701628 @default.
• W2095498603 cites W2028545813 @default.
• W2095498603 cites W2041971404 @default.
• W2095498603 cites W2064864485 @default.
• W2095498603 cites W2072233021 @default.
• W2095498603 cites W2077752826 @default.
• W2095498603 cites W2090086369 @default.
• W2095498603 cites W2094186244 @default.
• W2095498603 cites W2107066255 @default.
• W2095498603 cites W2109332166 @default.
• W2095498603 cites W2112686297 @default.
• W2095498603 cites W2116000210 @default.
• W2095498603 cites W2162166182 @default.
• W2095498603 doi "https://doi.org/10.1016/s0968-0896(98)00139-4" @default.
• W2095498603 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9839011" @default.
• W2095498603 hasPublicationYear "1998" @default.
• W2095498603 type Work @default.
• W2095498603 sameAs 2095498603 @default.
• W2095498603 citedByCount "48" @default.
• W2095498603 countsByYear W20954986032012 @default.
• W2095498603 countsByYear W20954986032013 @default.
• W2095498603 countsByYear W20954986032015 @default.
• W2095498603 countsByYear W20954986032019 @default.
• W2095498603 countsByYear W20954986032020 @default.
• W2095498603 countsByYear W20954986032021 @default.
• W2095498603 countsByYear W20954986032022 @default.
• W2095498603 countsByYear W20954986032023 @default.
• W2095498603 crossrefType "journal-article" @default.
• W2095498603 hasAuthorship W2095498603A5013346862 @default.
• W2095498603 hasAuthorship W2095498603A5040290706 @default.
• W2095498603 hasAuthorship W2095498603A5085399923 @default.
• W2095498603 hasConcept C107824862 @default.
• W2095498603 hasConcept C112887158 @default.
• W2095498603 hasConcept C178790620 @default.
• W2095498603 hasConcept C178910836 @default.
• W2095498603 hasConcept C181199279 @default.
• W2095498603 hasConcept C185592680 @default.
• W2095498603 hasConcept C194671627 @default.
• W2095498603 hasConcept C204921945 @default.
• W2095498603 hasConcept C2776439734 @default.
• W2095498603 hasConcept C2776851017 @default.
• W2095498603 hasConcept C2776980637 @default.
• W2095498603 hasConcept C2777374081 @default.
• W2095498603 hasConcept C2910800646 @default.
• W2095498603 hasConcept C32909587 @default.
• W2095498603 hasConcept C41183919 @default.
• W2095498603 hasConcept C521977710 @default.
• W2095498603 hasConcept C55493867 @default.
• W2095498603 hasConcept C56173144 @default.
• W2095498603 hasConcept C71240020 @default.
• W2095498603 hasConceptScore W2095498603C107824862 @default.
• W2095498603 hasConceptScore W2095498603C112887158 @default.
• W2095498603 hasConceptScore W2095498603C178790620 @default.
• W2095498603 hasConceptScore W2095498603C178910836 @default.
• W2095498603 hasConceptScore W2095498603C181199279 @default.
• W2095498603 hasConceptScore W2095498603C185592680 @default.
• W2095498603 hasConceptScore W2095498603C194671627 @default.
• W2095498603 hasConceptScore W2095498603C204921945 @default.
• W2095498603 hasConceptScore W2095498603C2776439734 @default.
• W2095498603 hasConceptScore W2095498603C2776851017 @default.
• W2095498603 hasConceptScore W2095498603C2776980637 @default.
• W2095498603 hasConceptScore W2095498603C2777374081 @default.
• W2095498603 hasConceptScore W2095498603C2910800646 @default.
• W2095498603 hasConceptScore W2095498603C32909587 @default.
• W2095498603 hasConceptScore W2095498603C41183919 @default.
• W2095498603 hasConceptScore W2095498603C521977710 @default.
• W2095498603 hasConceptScore W2095498603C55493867 @default.
• W2095498603 hasConceptScore W2095498603C56173144 @default.
• W2095498603 hasConceptScore W2095498603C71240020 @default.
• W2095498603 hasIssue "10" @default.
• W2095498603 hasLocation W20954986031 @default.
• W2095498603 hasLocation W20954986032 @default.
• W2095498603 hasOpenAccess W2095498603 @default.
• W2095498603 hasPrimaryLocation W20954986031 @default.
• W2095498603 hasRelatedWork W1539934907 @default.

• next