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- W2095503516 abstract "The effects of mild hyperthermia on bovine mammary epithelial cells exposed to 40 °C for 1 h were studied. The results showed that cell viability, ultrastructural features as well as mitochondrial function were significantly influenced by the mild heat treatment (40 °C). There was a considerate decrease in cell viability accompanied by cell loss resulting from apoptosis and necrosis followed by G2/M arrest. Cell death followed the typical cascade, namely decrease in the ratio of Bcl-2/Bax and mitochondrial membrane potential (ΔΨm), mitochondrial swelling and caspase-3 activities dramatically increased; DNA was also damaged. In conclusion, hyperthermia depresses cell viability and induces bovine mammary cell apoptosis and necrosis through the mitochondrial-triggered cell death pathway." @default.
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- W2095503516 date "2008-01-01" @default.
- W2095503516 modified "2023-09-23" @default.
- W2095503516 title "Hyperthermia causes bovine mammary epithelial cell death by a mitochondrial-induced pathway" @default.
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- W2095503516 doi "https://doi.org/10.1016/j.jtherbio.2007.06.002" @default.
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