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- W2095503800 abstract "To verify correlations between HLA and autism spectrum disorders (ASD) we studied 61 Italian families with an ASD child; results showed such correlation in 65% of cases. Case–control and TDT analysis of intrafamilial transmission of SNPs, Msats, and HLA markers surrounding the α and β blocks, indicated significant positive associations for MOGc*131 and D6S2239*105 alleles in ASD, and a negative association of MIB *332 allele in healthy siblings. Polymorphism haplotype analysis demonstrated that two haplotypes comprising the TNF-238(G)-TNF-308(G)-MIB*332-HLA-B*38-HLA-Cw*12 and the D6S265*218-HLA-A*23-MOGc*131-rs2857766(G) alleles are more frequently transmitted to ASD. MOGc and MIB loci are linked with ASD in Italian patients." @default.
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- W2095503800 date "2011-01-01" @default.
- W2095503800 modified "2023-09-26" @default.
- W2095503800 title "HLA polymorphisms in Italian children with autism spectrum disorders: Results of a family based linkage study" @default.
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- W2095503800 doi "https://doi.org/10.1016/j.jneuroim.2010.10.019" @default.
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