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- W2095504911 abstract "1. A method is described for measuring homovanillic acid, the major metabolite of dopamine, in human urine. Its assay provides a convenient index of dopamine production in the body. 2. The estimation involves the isolation of homovanillic acid from urine by extraction and silica gel chromatography, followed by demethylation to 3,4-dihydroxyphenylacetic acid, which is absorbed on alumina, removed with acid, and measured colorimetrically. 3. The procedure is sufficiently accurate to be used to follow physiological changes in homovanillic acid excretion, at the low concentration—5.1 ± 1.1 mg (S.D.) in 24 hr—found in normal adults. The standard of replication and the proximity to lineality of the recovery over the working range appears to be consistent with this claim. 4. The value of the method as an aid to the clinical diagnosis of dopamine-secreting tumors is demonstrated." @default.
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- W2095504911 date "1964-07-01" @default.
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- W2095504911 title "Estimation of homovanillic acid in urine" @default.
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- W2095504911 doi "https://doi.org/10.1016/0003-2697(64)90059-4" @default.
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