Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095507473> ?p ?o ?g. }
- W2095507473 endingPage "1643" @default.
- W2095507473 startingPage "1637" @default.
- W2095507473 abstract "Objective: The induction of deep cerebral hypothermia via ice-cold saline aortic flush during prolonged ventricular fibrillation cardiac arrest, followed by hypothermic stasis and delayed resuscitation (emergency preservation and resuscitation), improved neurologic outcome after cardiac arrest in pigs, as compared to conventional resuscitation. We hypothesized that emergency preservation and resuscitation with chest compressions would further improve outcome in the same model. Design: Prospective experimental study. Setting: University research laboratory. Subjects: Twenty-four female, large, white breed pigs (27–37 kg). Interventions: Fifteen minutes of ventricular fibrillation cardiac arrest were followed by 20 mins of resuscitation with chest compressions (control, n = 8), deep cerebral hypothermia via 200 mL/kg 4°C saline aortic flush and hypothermic stasis (emergency preservation and resuscitation, n = 8), and emergency preservation and resuscitation combined with chest compressions (emergency preservation and resuscitation plus chest compressions, n = 8). At 35 mins after cardiac arrest, cardiopulmonary bypass was initiated, followed by defibrillation. Mild hypothermia was continued for 20 hrs. Pigs were evaluated after 9 days using a neurologic deficit (neurologic deficit score: 100% = brain dead; 0%–10% = normal) and an overall performance category score (overall performance category score: 1 = normal; 2 = slightly handicapped; 3 = severely handicapped; 4 = comatose; 5 = dead/brain dead). Measurements and Main Results: Brain temperature decreased from 38.5°C to 15.3°C ± 3.3°C in the emergency preservation and resuscitation group, and to 11.3°C ± 1.2°C in the emergency preservation and resuscitation plus chest compressions group. In the control group, restoration of spontaneous circulation was achieved in four out of eight pigs, and one survived to 9 days. In the emergency preservation and resuscitation group, restoration of spontaneous circulation was achieved in seven out of eight pigs and five survived; in the emergency preservation and resuscitation plus chest compressions group, all had restoration of spontaneous circulation and seven survived (restoration of spontaneous circulation, p = .08). Neurologic outcome for (median and interquartile range) the control group included overall performance category score of 3, neurologic deficit score of 45%; for the emergency preservation and resuscitation group, overall performance category score was 3 (2–5) and neurologic deficit score was 45% (36; 50) and in the emergency preservation and resuscitation plus chest compressions group, overall performance category score was 2 (1–3) and neurologic deficit score was 13% (5; 21) (overall performance category score, p = .04; neurologic deficit score emergency preservation and resuscitation vs. emergency preservation and resuscitation plus chest compressions, p = .003). Conclusions: Emergency preservation and resuscitation by deep cerebral hypothermia combined with chest compressions during prolonged cardiac arrest in pigs are feasible and improve neurologic outcome." @default.
- W2095507473 created "2016-06-24" @default.
- W2095507473 creator A5002914523 @default.
- W2095507473 creator A5014687130 @default.
- W2095507473 creator A5015284423 @default.
- W2095507473 creator A5025137257 @default.
- W2095507473 creator A5036417017 @default.
- W2095507473 creator A5042010764 @default.
- W2095507473 creator A5042018975 @default.
- W2095507473 creator A5043214006 @default.
- W2095507473 creator A5053101106 @default.
- W2095507473 creator A5059920276 @default.
- W2095507473 creator A5065646501 @default.
- W2095507473 creator A5065747422 @default.
- W2095507473 creator A5083782243 @default.
- W2095507473 creator A5090139566 @default.
- W2095507473 date "2010-08-01" @default.
- W2095507473 modified "2023-09-23" @default.
- W2095507473 title "Cold aortic flush and chest compressions enable good neurologic outcome after 15 mins of ventricular fibrillation in cardiac arrest in pigs*" @default.
- W2095507473 cites W1560838288 @default.
- W2095507473 cites W1964928037 @default.
- W2095507473 cites W1969807137 @default.
- W2095507473 cites W1970212300 @default.
- W2095507473 cites W1971646874 @default.
- W2095507473 cites W1971822733 @default.
- W2095507473 cites W1974814120 @default.
- W2095507473 cites W1994684892 @default.
- W2095507473 cites W2006058191 @default.
- W2095507473 cites W2012077393 @default.
- W2095507473 cites W2018787568 @default.
- W2095507473 cites W2026353979 @default.
- W2095507473 cites W2026989777 @default.
- W2095507473 cites W2027585126 @default.
- W2095507473 cites W2030912227 @default.
- W2095507473 cites W2037464851 @default.
- W2095507473 cites W2038622826 @default.
- W2095507473 cites W2040748713 @default.
- W2095507473 cites W2041131288 @default.
- W2095507473 cites W2047034998 @default.
- W2095507473 cites W2049042164 @default.
- W2095507473 cites W2059997000 @default.
- W2095507473 cites W2080656191 @default.
- W2095507473 cites W2082171779 @default.
- W2095507473 cites W2085526114 @default.
- W2095507473 cites W2093163969 @default.
- W2095507473 cites W2104869294 @default.
- W2095507473 cites W2118153242 @default.
- W2095507473 cites W2121714044 @default.
- W2095507473 cites W2137834530 @default.
- W2095507473 cites W2139211697 @default.
- W2095507473 cites W2154227981 @default.
- W2095507473 cites W2161252442 @default.
- W2095507473 cites W2186288231 @default.
- W2095507473 cites W4248552398 @default.
- W2095507473 cites W4249375544 @default.
- W2095507473 doi "https://doi.org/10.1097/ccm.0b013e3181e78b9a" @default.
- W2095507473 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20543671" @default.
- W2095507473 hasPublicationYear "2010" @default.
- W2095507473 type Work @default.
- W2095507473 sameAs 2095507473 @default.
- W2095507473 citedByCount "22" @default.
- W2095507473 countsByYear W20955074732012 @default.
- W2095507473 countsByYear W20955074732013 @default.
- W2095507473 countsByYear W20955074732014 @default.
- W2095507473 countsByYear W20955074732015 @default.
- W2095507473 countsByYear W20955074732016 @default.
- W2095507473 countsByYear W20955074732017 @default.
- W2095507473 countsByYear W20955074732018 @default.
- W2095507473 countsByYear W20955074732019 @default.
- W2095507473 countsByYear W20955074732022 @default.
- W2095507473 crossrefType "journal-article" @default.
- W2095507473 hasAuthorship W2095507473A5002914523 @default.
- W2095507473 hasAuthorship W2095507473A5014687130 @default.
- W2095507473 hasAuthorship W2095507473A5015284423 @default.
- W2095507473 hasAuthorship W2095507473A5025137257 @default.
- W2095507473 hasAuthorship W2095507473A5036417017 @default.
- W2095507473 hasAuthorship W2095507473A5042010764 @default.
- W2095507473 hasAuthorship W2095507473A5042018975 @default.
- W2095507473 hasAuthorship W2095507473A5043214006 @default.
- W2095507473 hasAuthorship W2095507473A5053101106 @default.
- W2095507473 hasAuthorship W2095507473A5059920276 @default.
- W2095507473 hasAuthorship W2095507473A5065646501 @default.
- W2095507473 hasAuthorship W2095507473A5065747422 @default.
- W2095507473 hasAuthorship W2095507473A5083782243 @default.
- W2095507473 hasAuthorship W2095507473A5090139566 @default.
- W2095507473 hasConcept C164705383 @default.
- W2095507473 hasConcept C172408975 @default.
- W2095507473 hasConcept C2777055891 @default.
- W2095507473 hasConcept C2777390192 @default.
- W2095507473 hasConcept C2777795826 @default.
- W2095507473 hasConcept C2778165595 @default.
- W2095507473 hasConcept C2778619729 @default.
- W2095507473 hasConcept C2781005686 @default.
- W2095507473 hasConcept C42219234 @default.
- W2095507473 hasConcept C71924100 @default.
- W2095507473 hasConceptScore W2095507473C164705383 @default.
- W2095507473 hasConceptScore W2095507473C172408975 @default.
- W2095507473 hasConceptScore W2095507473C2777055891 @default.