FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095512229> ?p ?o ?g. }

• W2095512229 endingPage "354" @default.
• W2095512229 startingPage "343" @default.
• W2095512229 abstract "Long-term, low-dose macrolide therapy has been proven to improve survival in patients with diffuse panbronchiolitis and cystic fibrosis, although the mechanisms by which it does so remain unknown. To elucidate the molecular mechanisms of the anti-inflammatory effects of macrolides, the authors examined the effects of erythromycin (EM-A) and new derivative EM703 on transforming growth factor (TGF)-β /Smad signaling fibroblasts. EM-A and EM703 each inhibited fibroblast proliferation and the collagen production in human lung fibroblasts induced by TGF-β. EM-A and EM703 inhibited the augmentation of Smad3 mRNA induced by TGF-β. Smad7 mRNA was inhibited by TGF-β, but augmented by coincubation with EM-A or EM703. EM-A and EM703 each inhibited p-Smad2/3 proteins induced by TGF-β. Smad7 protein inhibited by TGF-β restored beyond basal level by EM-A and EM703. These findings suggest that EM-A and EM703 inhibit TGF-β signaling in human lung fibroblasts via inhibition of p-Smad2/3 through recovery of Smad7 level." @default.
• W2095512229 created "2016-06-24" @default.
• W2095512229 creator A5004425429 @default.
• W2095512229 creator A5018037140 @default.
• W2095512229 creator A5037262012 @default.
• W2095512229 creator A5045164227 @default.
• W2095512229 creator A5053644656 @default.
• W2095512229 creator A5070619122 @default.
• W2095512229 creator A5076431679 @default.
• W2095512229 creator A5078878264 @default.
• W2095512229 creator A5078931092 @default.
• W2095512229 creator A5083507260 @default.
• W2095512229 date "2008-01-01" @default.
• W2095512229 modified "2023-10-18" @default.
• W2095512229 title "EM703, A NEW DERIVATIVE OF ERYTHROMYCIN, INHIBITS TRANSFORMING GRWTH FACTOR-β SIGNALING IN HUMAN LUNG FIBROBLASTS" @default.
• W2095512229 cites W1537718629 @default.
• W2095512229 cites W1575094835 @default.
• W2095512229 cites W1995492033 @default.
• W2095512229 cites W2000708019 @default.
• W2095512229 cites W2018429730 @default.
• W2095512229 cites W2022779155 @default.
• W2095512229 cites W2034524575 @default.
• W2095512229 cites W2037620883 @default.
• W2095512229 cites W2054717462 @default.
• W2095512229 cites W2055141649 @default.
• W2095512229 cites W2072687919 @default.
• W2095512229 cites W2094579915 @default.
• W2095512229 cites W2106107897 @default.
• W2095512229 cites W2121246362 @default.
• W2095512229 cites W2128000778 @default.
• W2095512229 cites W2128743400 @default.
• W2095512229 cites W2135769782 @default.
• W2095512229 cites W2136312968 @default.
• W2095512229 cites W2138885527 @default.
• W2095512229 cites W2163987761 @default.
• W2095512229 cites W2317782431 @default.
• W2095512229 cites W4297022993 @default.
• W2095512229 cites W4365787052 @default.
• W2095512229 doi "https://doi.org/10.1080/01902140802093238" @default.
• W2095512229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18600500" @default.
• W2095512229 hasPublicationYear "2008" @default.
• W2095512229 type Work @default.
• W2095512229 sameAs 2095512229 @default.
• W2095512229 citedByCount "12" @default.
• W2095512229 countsByYear W20955122292012 @default.
• W2095512229 countsByYear W20955122292013 @default.
• W2095512229 countsByYear W20955122292014 @default.
• W2095512229 countsByYear W20955122292017 @default.
• W2095512229 countsByYear W20955122292020 @default.
• W2095512229 crossrefType "journal-article" @default.
• W2095512229 hasAuthorship W2095512229A5004425429 @default.
• W2095512229 hasAuthorship W2095512229A5018037140 @default.
• W2095512229 hasAuthorship W2095512229A5037262012 @default.
• W2095512229 hasAuthorship W2095512229A5045164227 @default.
• W2095512229 hasAuthorship W2095512229A5053644656 @default.
• W2095512229 hasAuthorship W2095512229A5070619122 @default.
• W2095512229 hasAuthorship W2095512229A5076431679 @default.
• W2095512229 hasAuthorship W2095512229A5078878264 @default.
• W2095512229 hasAuthorship W2095512229A5078931092 @default.
• W2095512229 hasAuthorship W2095512229A5083507260 @default.
• W2095512229 hasBestOaLocation W20955122291 @default.
• W2095512229 hasConcept C118131993 @default.
• W2095512229 hasConcept C126322002 @default.
• W2095512229 hasConcept C134018914 @default.
• W2095512229 hasConcept C185592680 @default.
• W2095512229 hasConcept C202751555 @default.
• W2095512229 hasConcept C2776388485 @default.
• W2095512229 hasConcept C2776938444 @default.
• W2095512229 hasConcept C2777714996 @default.
• W2095512229 hasConcept C2780206985 @default.
• W2095512229 hasConcept C2780381497 @default.
• W2095512229 hasConcept C2780559512 @default.
• W2095512229 hasConcept C2781080636 @default.
• W2095512229 hasConcept C501593827 @default.
• W2095512229 hasConcept C502942594 @default.
• W2095512229 hasConcept C55493867 @default.
• W2095512229 hasConcept C62478195 @default.
• W2095512229 hasConcept C71924100 @default.
• W2095512229 hasConcept C86803240 @default.
• W2095512229 hasConcept C95444343 @default.
• W2095512229 hasConceptScore W2095512229C118131993 @default.
• W2095512229 hasConceptScore W2095512229C126322002 @default.
• W2095512229 hasConceptScore W2095512229C134018914 @default.
• W2095512229 hasConceptScore W2095512229C185592680 @default.
• W2095512229 hasConceptScore W2095512229C202751555 @default.
• W2095512229 hasConceptScore W2095512229C2776388485 @default.
• W2095512229 hasConceptScore W2095512229C2776938444 @default.
• W2095512229 hasConceptScore W2095512229C2777714996 @default.
• W2095512229 hasConceptScore W2095512229C2780206985 @default.
• W2095512229 hasConceptScore W2095512229C2780381497 @default.
• W2095512229 hasConceptScore W2095512229C2780559512 @default.
• W2095512229 hasConceptScore W2095512229C2781080636 @default.
• W2095512229 hasConceptScore W2095512229C501593827 @default.
• W2095512229 hasConceptScore W2095512229C502942594 @default.
• W2095512229 hasConceptScore W2095512229C55493867 @default.
• W2095512229 hasConceptScore W2095512229C62478195 @default.
• W2095512229 hasConceptScore W2095512229C71924100 @default.
• W2095512229 hasConceptScore W2095512229C86803240 @default.

• next