FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095514056> ?p ?o ?g. }

• W2095514056 endingPage "e1003615" @default.
• W2095514056 startingPage "e1003615" @default.
• W2095514056 abstract "Post-synaptic potential (PSP) variability is typically attributed to mechanisms inside synapses, yet recent advances in experimental methods and biophysical understanding have led us to reconsider the role of axons as highly reliable transmission channels. We show that in many thin axons of our brain, the action potential (AP) waveform and thus the Ca++ signal controlling vesicle release at synapses will be significantly affected by the inherent variability of ion channel gating. We investigate how and to what extent fluctuations in the AP waveform explain observed PSP variability. Using both biophysical theory and stochastic simulations of central and peripheral nervous system axons from vertebrates and invertebrates, we show that channel noise in thin axons (<1 µm diameter) causes random fluctuations in AP waveforms. AP height and width, both experimentally characterised parameters of post-synaptic response amplitude, vary e.g. by up to 20 mV and 0.5 ms while a single AP propagates in C-fibre axons. We show how AP height and width variabilities increase with a ¾ power-law as diameter decreases and translate these fluctuations into post-synaptic response variability using biophysical data and models of synaptic transmission. We find for example that for mammalian unmyelinated axons with 0.2 µm diameter (matching cerebellar parallel fibres) axonal noise alone can explain half of the PSP variability in cerebellar synapses. We conclude that axonal variability may have considerable impact on synaptic response variability. Thus, in many experimental frameworks investigating synaptic transmission through paired-cell recordings or extracellular stimulation of presynaptic neurons, causes of variability may have been confounded. We thereby show how bottom-up aggregation of molecular noise sources contributes to our understanding of variability observed at higher levels of biological organisation." @default.
• W2095514056 created "2016-06-24" @default.
• W2095514056 creator A5003765514 @default.
• W2095514056 creator A5060700722 @default.
• W2095514056 date "2014-05-08" @default.
• W2095514056 modified "2023-10-09" @default.
• W2095514056 title "Axonal Noise as a Source of Synaptic Variability" @default.
• W2095514056 cites W1501360999 @default.
• W2095514056 cites W1524865348 @default.
• W2095514056 cites W1603661052 @default.
• W2095514056 cites W1640265418 @default.
• W2095514056 cites W1642181682 @default.
• W2095514056 cites W1664184517 @default.
• W2095514056 cites W1667367966 @default.
• W2095514056 cites W1673091991 @default.
• W2095514056 cites W1786317442 @default.
• W2095514056 cites W1847049425 @default.
• W2095514056 cites W1859669881 @default.
• W2095514056 cites W1965411113 @default.
• W2095514056 cites W1967507965 @default.
• W2095514056 cites W1983326785 @default.
• W2095514056 cites W1983446016 @default.
• W2095514056 cites W1984308273 @default.
• W2095514056 cites W1985940938 @default.
• W2095514056 cites W1989124771 @default.
• W2095514056 cites W1989577442 @default.
• W2095514056 cites W1993673892 @default.
• W2095514056 cites W2023004141 @default.
• W2095514056 cites W2023097449 @default.
• W2095514056 cites W2024159878 @default.
• W2095514056 cites W2024345785 @default.
• W2095514056 cites W2028226828 @default.
• W2095514056 cites W2035018673 @default.
• W2095514056 cites W2038556096 @default.
• W2095514056 cites W2039804216 @default.
• W2095514056 cites W2042447398 @default.
• W2095514056 cites W2048635483 @default.
• W2095514056 cites W2051380496 @default.
• W2095514056 cites W2052006707 @default.
• W2095514056 cites W2055850859 @default.
• W2095514056 cites W2061655858 @default.
• W2095514056 cites W2067775417 @default.
• W2095514056 cites W2068662533 @default.
• W2095514056 cites W2069764948 @default.
• W2095514056 cites W2071365886 @default.
• W2095514056 cites W2074413930 @default.
• W2095514056 cites W2075183645 @default.
• W2095514056 cites W2075400046 @default.
• W2095514056 cites W2075770222 @default.
• W2095514056 cites W2076188650 @default.
• W2095514056 cites W2078841808 @default.
• W2095514056 cites W2082326637 @default.
• W2095514056 cites W2085957678 @default.
• W2095514056 cites W2087176067 @default.
• W2095514056 cites W2087758815 @default.
• W2095514056 cites W2094930349 @default.
• W2095514056 cites W2098599651 @default.
• W2095514056 cites W2101439630 @default.
• W2095514056 cites W2104727590 @default.
• W2095514056 cites W2105609812 @default.
• W2095514056 cites W2108270932 @default.
• W2095514056 cites W2110095865 @default.
• W2095514056 cites W2110402020 @default.
• W2095514056 cites W2116039123 @default.
• W2095514056 cites W2119494356 @default.
• W2095514056 cites W2130453501 @default.
• W2095514056 cites W2130753066 @default.
• W2095514056 cites W2131215403 @default.
• W2095514056 cites W2131338541 @default.
• W2095514056 cites W2133437351 @default.
• W2095514056 cites W2133673540 @default.
• W2095514056 cites W2136153614 @default.
• W2095514056 cites W2139055855 @default.
• W2095514056 cites W2139621297 @default.
• W2095514056 cites W2147142375 @default.
• W2095514056 cites W2149618862 @default.
• W2095514056 cites W2149729560 @default.
• W2095514056 cites W2151526807 @default.
• W2095514056 cites W2158561409 @default.
• W2095514056 cites W2171298127 @default.
• W2095514056 cites W2172225359 @default.
• W2095514056 cites W2175956536 @default.
• W2095514056 cites W4211163766 @default.
• W2095514056 cites W4300763086 @default.
• W2095514056 cites W124449151 @default.
• W2095514056 doi "https://doi.org/10.1371/journal.pcbi.1003615" @default.
• W2095514056 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4014398" @default.
• W2095514056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24809823" @default.
• W2095514056 hasPublicationYear "2014" @default.
• W2095514056 type Work @default.
• W2095514056 sameAs 2095514056 @default.
• W2095514056 citedByCount "34" @default.
• W2095514056 countsByYear W20955140562014 @default.
• W2095514056 countsByYear W20955140562015 @default.
• W2095514056 countsByYear W20955140562016 @default.
• W2095514056 countsByYear W20955140562017 @default.
• W2095514056 countsByYear W20955140562018 @default.
• W2095514056 countsByYear W20955140562019 @default.

• next