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- W2095514207 abstract "The apolipoprotein E (APOE) gene is strongly associated to the risk of Alzheimer's disease (AD). More specifically, it seems undisputed that the APOE*4 allele plays an important role in the pathogenesis of AD. However, does this imply that it is ApoE4 which causes the increased susceptibility for AD? Empirical findings in non-Caucasians leave space for at least one alternative hypothesis: not the ApoE4 polymorphism but other defects in, or close to the APOE gene, could be responsible. We discuss this hypothesis, based on population and evolutionary genetic evidence." @default.
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- W2095514207 date "1998-01-01" @default.
- W2095514207 modified "2023-10-16" @default.
- W2095514207 title "Role of APOE in Dementia:A Critical Reappraisal" @default.
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- W2095514207 doi "https://doi.org/10.1159/000022430" @default.
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