FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095528423> ?p ?o ?g. }

• W2095528423 endingPage "134" @default.
• W2095528423 startingPage "127" @default.
• W2095528423 abstract "Background. Oxidant molecules and nitric oxide (NO) have each been implicated as mediators of endothelial cell damage, but the biologic effect of these molecules acting in concert is incompletely understood. Materials and methods. We studied the effects of an NO donor,S-nitroso-acetyl-d,l-penicillamine (SNAP), in combination with the peroxidantstert-butyl hydroperoxide (TBH) and hydrogen peroxide (H2O2) on rabbit aortic endothelial cells in culture. Cell viability was assessed using Alamar blue, a nontoxic dye indicator of cell metabolism. Lipid peroxidation was assessed using a chemiluminescent single-photon counting technique. Results. After 90 min exposure to test reagents, there was concentration-dependent cytotoxicity for both TBH and H2O2. Peroxidant-induced cytotoxicity was significantly ameliorated by SNAP (10−4–10−3M).N-Acetylpenicillamine and NO-depleted SNAP failed to demonstrate a cytoprotective effect against peroxidant cellular injury, thus implicating NO as the agent responsible for the protective effect. SNAP reduced lipid peroxidation caused by 10−3M TBH in a dose-dependent manner. Preincubation of cells with SNAP before exposure to peroxidants alone had no effect on toxicity. Conclusions. NO is cytoprotective to the endothelium in the presence of peroxidants through a reduction of lipid peroxidation." @default.
• W2095528423 created "2016-06-24" @default.
• W2095528423 creator A5012947447 @default.
• W2095528423 creator A5028028660 @default.
• W2095528423 creator A5049165872 @default.
• W2095528423 creator A5073935908 @default.
• W2095528423 creator A5076314755 @default.
• W2095528423 date "1998-03-01" @default.
• W2095528423 modified "2023-09-27" @default.
• W2095528423 title "Nitric Oxide Inhibits Peroxide-Mediated Endothelial Toxicity" @default.
• W2095528423 cites W1489860413 @default.
• W2095528423 cites W1986611432 @default.
• W2095528423 cites W1987165240 @default.
• W2095528423 cites W1993476394 @default.
• W2095528423 cites W1999781532 @default.
• W2095528423 cites W2001931708 @default.
• W2095528423 cites W2022086508 @default.
• W2095528423 cites W2030816483 @default.
• W2095528423 cites W2043134209 @default.
• W2095528423 cites W2044992987 @default.
• W2095528423 cites W2050922265 @default.
• W2095528423 cites W2058137293 @default.
• W2095528423 cites W2062602696 @default.
• W2095528423 cites W2071756355 @default.
• W2095528423 cites W2073278082 @default.
• W2095528423 cites W2079873257 @default.
• W2095528423 cites W2086800606 @default.
• W2095528423 cites W2091045350 @default.
• W2095528423 cites W2097744068 @default.
• W2095528423 cites W2114839966 @default.
• W2095528423 cites W2122340134 @default.
• W2095528423 cites W2416382853 @default.
• W2095528423 doi "https://doi.org/10.1006/jsre.1998.5270" @default.
• W2095528423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9655085" @default.
• W2095528423 hasPublicationYear "1998" @default.
• W2095528423 type Work @default.
• W2095528423 sameAs 2095528423 @default.
• W2095528423 citedByCount "21" @default.
• W2095528423 countsByYear W20955284232012 @default.
• W2095528423 countsByYear W20955284232014 @default.
• W2095528423 countsByYear W20955284232015 @default.
• W2095528423 countsByYear W20955284232017 @default.
• W2095528423 countsByYear W20955284232018 @default.
• W2095528423 crossrefType "journal-article" @default.
• W2095528423 hasAuthorship W2095528423A5012947447 @default.
• W2095528423 hasAuthorship W2095528423A5028028660 @default.
• W2095528423 hasAuthorship W2095528423A5049165872 @default.
• W2095528423 hasAuthorship W2095528423A5073935908 @default.
• W2095528423 hasAuthorship W2095528423A5076314755 @default.
• W2095528423 hasConcept C109316439 @default.
• W2095528423 hasConcept C121684516 @default.
• W2095528423 hasConcept C123012128 @default.
• W2095528423 hasConcept C134018914 @default.
• W2095528423 hasConcept C1491633281 @default.
• W2095528423 hasConcept C178790620 @default.
• W2095528423 hasConcept C185592680 @default.
• W2095528423 hasConcept C202751555 @default.
• W2095528423 hasConcept C2776151105 @default.
• W2095528423 hasConcept C2776992346 @default.
• W2095528423 hasConcept C2779997099 @default.
• W2095528423 hasConcept C2780829032 @default.
• W2095528423 hasConcept C29730261 @default.
• W2095528423 hasConcept C2993790521 @default.
• W2095528423 hasConcept C41008148 @default.
• W2095528423 hasConcept C519581460 @default.
• W2095528423 hasConcept C53227056 @default.
• W2095528423 hasConcept C533411734 @default.
• W2095528423 hasConcept C55493867 @default.
• W2095528423 hasConcept C86803240 @default.
• W2095528423 hasConcept C98274493 @default.
• W2095528423 hasConceptScore W2095528423C109316439 @default.
• W2095528423 hasConceptScore W2095528423C121684516 @default.
• W2095528423 hasConceptScore W2095528423C123012128 @default.
• W2095528423 hasConceptScore W2095528423C134018914 @default.
• W2095528423 hasConceptScore W2095528423C1491633281 @default.
• W2095528423 hasConceptScore W2095528423C178790620 @default.
• W2095528423 hasConceptScore W2095528423C185592680 @default.
• W2095528423 hasConceptScore W2095528423C202751555 @default.
• W2095528423 hasConceptScore W2095528423C2776151105 @default.
• W2095528423 hasConceptScore W2095528423C2776992346 @default.
• W2095528423 hasConceptScore W2095528423C2779997099 @default.
• W2095528423 hasConceptScore W2095528423C2780829032 @default.
• W2095528423 hasConceptScore W2095528423C29730261 @default.
• W2095528423 hasConceptScore W2095528423C2993790521 @default.
• W2095528423 hasConceptScore W2095528423C41008148 @default.
• W2095528423 hasConceptScore W2095528423C519581460 @default.
• W2095528423 hasConceptScore W2095528423C53227056 @default.
• W2095528423 hasConceptScore W2095528423C533411734 @default.
• W2095528423 hasConceptScore W2095528423C55493867 @default.
• W2095528423 hasConceptScore W2095528423C86803240 @default.
• W2095528423 hasConceptScore W2095528423C98274493 @default.
• W2095528423 hasIssue "2" @default.
• W2095528423 hasLocation W20955284231 @default.
• W2095528423 hasLocation W20955284232 @default.
• W2095528423 hasOpenAccess W2095528423 @default.
• W2095528423 hasPrimaryLocation W20955284231 @default.
• W2095528423 hasRelatedWork W1589090458 @default.
• W2095528423 hasRelatedWork W1978271236 @default.

• next